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- W1992464436 abstract "Many commercially available, weakly basic drugs have been shown to be lysosomotropic, meaning they are subject to extensive sequestration in lysosomes through an ion trapping-type mechanism. The extent of lysosomal trapping of a drug is an important therapeutic consideration because it can influence both activity and pharmacokinetic disposition. The administration of certain drugs can alter lysosomes such that their accumulation capacity for co-administered and/or secondarily administered drugs is altered.In this review the authors explore what is known regarding the mechanistic basis for drug-drug interactions involving lysosomes. Specifically, the authors address the influence of drugs on lysosomal pH, volume and lipid processing.Many drugs are known to extensively accumulate in lysosomes and significantly alter their structure and function; however, the therapeutic and toxicological implications of this remain controversial. The authors propose that drug-drug interactions involving lysosomes represent an important potential source of variability in drug activity and pharmacokinetics. Most evaluations of drug-drug interactions involving lysosomes have been performed in cultured cells and isolated tissues. More comprehensive in vivo evaluations are needed to fully explore the impact of this drug-drug interaction pathway on therapeutic outcomes." @default.
- W1992464436 created "2016-06-24" @default.
- W1992464436 creator A5001486285 @default.
- W1992464436 creator A5012209059 @default.
- W1992464436 creator A5049457673 @default.
- W1992464436 creator A5072245016 @default.
- W1992464436 date "2012-05-22" @default.
- W1992464436 modified "2023-10-06" @default.
- W1992464436 title "<b>Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications</b>" @default.
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- W1992464436 doi "https://doi.org/10.1517/17425255.2012.691165" @default.
- W1992464436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22616667" @default.
- W1992464436 hasPublicationYear "2012" @default.
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