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- W1992466503 abstract "Vascular responses of isolated perfused kidneys to norepinephrine, angiotensin II and KCl were examined in stroke-prone spontaneously hypertensive rats (SHR-SP), stroke-resistant SHR (SHR-SR) and control Wistar Kyoto rats (WKR) at 8 to 10 weeks of age. Average values of systolic blood pressure were 181, 155 and 122 mmHg in the SHR-SP, SHR-SR and WKR, respectively. Basal renal vascular resistance was identical among these rats. In response to norepinephrine, the SHR-SP demonstrated shift in the dose-response curve to the left and lower vasoconstrictor threshold than the controls. The SHR-SR was intermediate between the SHR-SP and the controls in the response to norepinephrine. For angiostein II, the SHR-SP but not SHR-SR displayed a slightly greater response than the controls. However, response to KCl was not significantly different among these three strains of rats. The results suggest that the SHR-SP rats have an intrinsic augmentation of renal vascular reactivity to norepinephrine, which in turn leads to rapid elevation of blood pressure at the early hypertensive stage." @default.
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- W1992466503 date "1978-09-01" @default.
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- W1992466503 title "Increased renal vascular reactivity to norepinephrine in stroke-prone spontaneously hypertensive rat (SHR)" @default.
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- W1992466503 doi "https://doi.org/10.1016/0024-3205(78)90350-8" @default.
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