FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992470912> ?p ?o ?g. }

• W1992470912 endingPage "93" @default.
• W1992470912 startingPage "89" @default.
• W1992470912 abstract "We have studied the cytotoxicity and accumulation of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres in a model of doxorubicin-resistant rat glioblastoma variants differing by their degree of resistance to this drug. We observed that the particulate form of doxorubicin was always more cytotoxic than free doxorubicin, whereas coadministration of drug-unloaded nanospheres with free doxorubicin did not modify significantly doxorubicin cytotoxicity. In C6 0.001 cells, which were 6-fold resistant and present a pure multidrug-resistant phenotype, the reversal of doxorubicin resistance was complete. In C6 0.1 cells, which were 60-fold resistant, as with C6 1V cells (selected with vincristine), the reversal of doxorubicin resistance was almost complete, with a residual resistance factor of 2–3. In C6 0.5 cells, which were 600-fold resistant to doxorubicin, the reversal of resistance was only partial and, in all cases, not above the expected participation of P-glycoprotein to the phenotype of resistance. Intracellular drug accumulation after 2-h exposure to 17.2 μmol/l doxorubicin was systematically reduced by a factor of 2–3 when doxorubicin was incubated under the form of nanospheres; doxorubicin accumulation after a 2-h exposure to IC50 was also highly reduced in all cell lines for doxorubicinloaded nanospheres. This work shows that association of doxorubicin with nanoparticles could provide a useful tool for circumventing multidrug resistance, probably by a bypass of P-glycoprotein rather than by an inhibition of this pump. We have studied the cytotoxicity and accumulation of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres in a model of doxorubicin-resistant rat glioblastoma variants differing by their degree of resistance to this drug. We observed that the particulate form of doxorubicin was always more cytotoxic than free doxorubicin, whereas coadministration of drug-unloaded nanospheres with free doxorubicin did not modify significantly doxorubicin cytotoxicity. In C6 0.001 cells, which were 6-fold resistant and present a pure multidrug-resistant phenotype, the reversal of doxorubicin resistance was complete. In C6 0.1 cells, which were 60-fold resistant, as with C6 1V cells (selected with vincristine), the reversal of doxorubicin resistance was almost complete, with a residual resistance factor of 2–3. In C6 0.5 cells, which were 600-fold resistant to doxorubicin, the reversal of resistance was only partial and, in all cases, not above the expected participation of P-glycoprotein to the phenotype of resistance. Intracellular drug accumulation after 2-h exposure to 17.2 μmol/l doxorubicin was systematically reduced by a factor of 2–3 when doxorubicin was incubated under the form of nanospheres; doxorubicin accumulation after a 2-h exposure to IC50 was also highly reduced in all cell lines for doxorubicinloaded nanospheres. This work shows that association of doxorubicin with nanoparticles could provide a useful tool for circumventing multidrug resistance, probably by a bypass of P-glycoprotein rather than by an inhibition of this pump." @default.
• W1992470912 created "2016-06-24" @default.
• W1992470912 creator A5015122849 @default.
• W1992470912 creator A5040426953 @default.
• W1992470912 creator A5060017701 @default.
• W1992470912 creator A5078174247 @default.
• W1992470912 date "1994-01-01" @default.
• W1992470912 modified "2023-10-15" @default.
• W1992470912 title "Enhanced cytotoxicity of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres against multidrug-resistant tumour cells in culture" @default.
• W1992470912 cites W1775749144 @default.
• W1992470912 cites W1966887301 @default.
• W1992470912 cites W1979265285 @default.
• W1992470912 cites W1990918868 @default.
• W1992470912 cites W1998773179 @default.
• W1992470912 cites W2013256537 @default.
• W1992470912 cites W2024811504 @default.
• W1992470912 cites W2067687009 @default.
• W1992470912 cites W2077361516 @default.
• W1992470912 cites W2080345216 @default.
• W1992470912 cites W2081150848 @default.
• W1992470912 cites W2090176470 @default.
• W1992470912 cites W2103970111 @default.
• W1992470912 cites W2113214957 @default.
• W1992470912 cites W2125112635 @default.
• W1992470912 cites W2615953705 @default.
• W1992470912 doi "https://doi.org/10.1016/s0959-8049(05)80025-5" @default.
• W1992470912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8142172" @default.
• W1992470912 hasPublicationYear "1994" @default.
• W1992470912 type Work @default.
• W1992470912 sameAs 1992470912 @default.
• W1992470912 citedByCount "128" @default.
• W1992470912 countsByYear W19924709122012 @default.
• W1992470912 countsByYear W19924709122013 @default.
• W1992470912 countsByYear W19924709122015 @default.
• W1992470912 countsByYear W19924709122016 @default.
• W1992470912 countsByYear W19924709122017 @default.
• W1992470912 countsByYear W19924709122018 @default.
• W1992470912 countsByYear W19924709122019 @default.
• W1992470912 countsByYear W19924709122020 @default.
• W1992470912 countsByYear W19924709122021 @default.
• W1992470912 countsByYear W19924709122022 @default.
• W1992470912 countsByYear W19924709122023 @default.
• W1992470912 crossrefType "journal-article" @default.
• W1992470912 hasAuthorship W1992470912A5015122849 @default.
• W1992470912 hasAuthorship W1992470912A5040426953 @default.
• W1992470912 hasAuthorship W1992470912A5060017701 @default.
• W1992470912 hasAuthorship W1992470912A5078174247 @default.
• W1992470912 hasConcept C109316439 @default.
• W1992470912 hasConcept C114851261 @default.
• W1992470912 hasConcept C126322002 @default.
• W1992470912 hasConcept C133936738 @default.
• W1992470912 hasConcept C154317977 @default.
• W1992470912 hasConcept C185592680 @default.
• W1992470912 hasConcept C200082930 @default.
• W1992470912 hasConcept C202751555 @default.
• W1992470912 hasConcept C2776694085 @default.
• W1992470912 hasConcept C2776755627 @default.
• W1992470912 hasConcept C2777752497 @default.
• W1992470912 hasConcept C2778707650 @default.
• W1992470912 hasConcept C2779429289 @default.
• W1992470912 hasConcept C2781303535 @default.
• W1992470912 hasConcept C502942594 @default.
• W1992470912 hasConcept C54355233 @default.
• W1992470912 hasConcept C55493867 @default.
• W1992470912 hasConcept C71924100 @default.
• W1992470912 hasConcept C79879829 @default.
• W1992470912 hasConcept C81885089 @default.
• W1992470912 hasConcept C86803240 @default.
• W1992470912 hasConcept C89423630 @default.
• W1992470912 hasConcept C98274493 @default.
• W1992470912 hasConceptScore W1992470912C109316439 @default.
• W1992470912 hasConceptScore W1992470912C114851261 @default.
• W1992470912 hasConceptScore W1992470912C126322002 @default.
• W1992470912 hasConceptScore W1992470912C133936738 @default.
• W1992470912 hasConceptScore W1992470912C154317977 @default.
• W1992470912 hasConceptScore W1992470912C185592680 @default.
• W1992470912 hasConceptScore W1992470912C200082930 @default.
• W1992470912 hasConceptScore W1992470912C202751555 @default.
• W1992470912 hasConceptScore W1992470912C2776694085 @default.
• W1992470912 hasConceptScore W1992470912C2776755627 @default.
• W1992470912 hasConceptScore W1992470912C2777752497 @default.
• W1992470912 hasConceptScore W1992470912C2778707650 @default.
• W1992470912 hasConceptScore W1992470912C2779429289 @default.
• W1992470912 hasConceptScore W1992470912C2781303535 @default.
• W1992470912 hasConceptScore W1992470912C502942594 @default.
• W1992470912 hasConceptScore W1992470912C54355233 @default.
• W1992470912 hasConceptScore W1992470912C55493867 @default.
• W1992470912 hasConceptScore W1992470912C71924100 @default.
• W1992470912 hasConceptScore W1992470912C79879829 @default.
• W1992470912 hasConceptScore W1992470912C81885089 @default.
• W1992470912 hasConceptScore W1992470912C86803240 @default.
• W1992470912 hasConceptScore W1992470912C89423630 @default.
• W1992470912 hasConceptScore W1992470912C98274493 @default.
• W1992470912 hasIssue "1" @default.
• W1992470912 hasLocation W19924709121 @default.
• W1992470912 hasLocation W19924709122 @default.
• W1992470912 hasOpenAccess W1992470912 @default.
• W1992470912 hasPrimaryLocation W19924709121 @default.

• next