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- W1992483971 abstract "Abstract The ability of temperature to influence insulin binding, hormone stimulation of glucose transport, and the coupling of these two events was studied in isolated rat adipocytes. Insulin binding was reduced as the temperature rose from 16°C to 37°C. Both total and cell surface binding varied in an inverse linear manner with temperature, and Scatchard analysis suggested that this was caused by an altered affinity with no change in receptor number. The insulin responsiveness of 3-O-methyl-glucose transport increased with temperature from a four-fold stimulation at 16°C to 12-fold at 37°C. Insulin sensitivity was also higher at elevated temperatures with the EC50 at 37°C (0.3 ng/mL) one-third that at 16°C (0.9 ng/mL). The stimulation by a single insulin concentration (0.75 ng/mL) varied linearly with temperature. Since the amount of cell-associated insulin that was internalized (non-acid extractable) also increased in a linear fashion with temperature, it was possible to compare the amount of insulin binding to the cell surface needed to attain a certain effect. At 37°C half-maximal stimulation was seen when each cell bound 1255 insulin molecules. The same level of effect required 2510 molecules per cell at 24°C and 6024 molecules per cell at 16°C. These results reveal several things about the insulin-response sequence in fat cells: (1) both total cell and cell surface binding vary inversely with temperature; (2) both insulin responsiveness and sensitivity increase with temperature; (3) the opposing behaviors of binding and sensitivity result in an increase in the effect of a set amount of insulin bound (the coupling efficiency); and (4) the coupling process between insulin receptors and glucose transport is regulated by temperature and could be subject to control by other physiologic factors." @default.
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- W1992483971 date "1983-10-01" @default.
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- W1992483971 title "Effect of temperature on coupling of insulin receptors to stimulation of glucose transport in isolated rat adipocytes" @default.
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- W1992483971 doi "https://doi.org/10.1016/0026-0495(83)90143-9" @default.
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