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- W1992485791 abstract "Aims Low-grade mucosa-associated lymphoid tissue (MALT) lymphoma and high-grade B-cell non-Hodgkin's lymphoma (NHL) of the stomach may occur simultaneously. To determine the clonal relationship between these tumours, we compared the immunoglobulin heavy chain gene (IgH) rearrangements of low and high-grade components of a multifocal gastric NHL. Methods and results The complementary determining region 3 (CDR3) of the IgH gene rearrangements were polymerase chain reaction (PCR) amplified, cloned and sequenced. The analysis of the CDR3 sequences rearranged by tumour cells of low-grade MALT and the high-grade NHL revealed different nucleic acid sequences. Conclusion These findings suggest that low-grade MALT and high-grade B-cell components of multifocal gastric NHL may represent unrelated clones." @default.
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- W1992485791 date "1999-01-01" @default.
- W1992485791 modified "2023-10-15" @default.
- W1992485791 title "Distinct clonal origin of low-grade MALT-type and high-grade lesions of a multifocal gastric lymphoma" @default.
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- W1992485791 doi "https://doi.org/10.1046/j.1365-2559.1999.00568.x" @default.
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