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• W1992500853 abstract "The concepts of 'drug-like' and 'lead-like' chemical properties are having a major influence on the selection of compounds for high-throughput screening, and in the design of lead generation libraries. Medicinal chemists are recycling 'privileged' drug-like structures, whilst aiming to seek optimal physical properties for oral delivery. This approach biases the chemical profiles of compound screening collections towards known structures. Novel library synthesis, creating new chemical classes to address intellectual property, toxicity issues, and less chemically tractable targets, though considered risky, is warranted.:" @default.
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• W1992500853 date "2004-12-01" @default.
• W1992500853 modified "2023-09-26" @default.
• W1992500853 title "Drug-like properties: guiding principles for design – or chemical prejudice?" @default.
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• W1992500853 doi "https://doi.org/10.1016/j.ddtec.2004.11.005" @default.
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