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- W1992505893 abstract "Peptide design for unassisted passive water−lipid translocation remains a challenge, notwithstanding its importance for drug delivery. We introduce a design paradigm based on conformational switches operating as passive translocation vehicles. The interfacial behavior of the molecular prototype, probed in single-molecule AFM experiments, reveals a near-barrierless translocation. The associated free-energy agrees with mesoscopic measurements, and the in vitro behavior is quantitatively reproduced in cellular assays. The prototypes herald the advent of novel nanobiomaterials for passive translocation." @default.
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- W1992505893 date "2007-12-01" @default.
- W1992505893 modified "2023-10-14" @default.
- W1992505893 title "Passive Water−Lipid Peptide Translocators with Conformational Switches: From Single-Molecule Probe to Cellular Assay" @default.
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- W1992505893 doi "https://doi.org/10.1021/jp074479u" @default.
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