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- W1992508595 abstract "Thin-layer chromatographic (TLC) methods were developed for pharmacokinetic studies of major metamizole metabolites in serum and urine. These methods proved practicable, selective, accurate and sensitive with detection limits as follows: 4-methylaminoantipyrine 0.6 micrograms/ml serum and 2.0 micrograms/ml urine; 4-aminoantipyrine 0.16 micrograms/ml serum and 1.0 micrograms/ml urine; 4-acetylaminoantipyrine 0.14 micrograms/ml serum and 0.6 micrograms/ml urine; 4-formylaminoantipyrine 0.12 micrograms/ml serum and 1.0 micrograms/ml urine. Samples of 250 microliter suffice for TLC analysis. Following chromatographic separation, detection is performed in the ultraviolet range at 265 nm. Serum and urine levels were determined following a single oral dose of 1 g of metamizole sodium to eight volunteers. These results were compared with those following an accidental overdose of 49 g." @default.
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- W1992508595 date "1983-01-01" @default.
- W1992508595 modified "2023-09-27" @default.
- W1992508595 title "Thin-layer chromatographic determination of major metamizole metabolites in serum and urine" @default.
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- W1992508595 doi "https://doi.org/10.1016/s0378-4347(00)84432-1" @default.
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