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• W1992511140 abstract "By light and electron microscopy we studied the sinus nodes and atrioventricular (AV) conducting tissue of six C3H/He mice having coxsackievirus B3 acute myocarditis. Sinus arrest was documented in all six mice, and second- or third-degree AV block was documented in three of the six mice. Although myocarditic changes in the conduction system, especially in the sinus node, were less than those in atrial and ventricular working myocardium, there were distinct abnormalities within both the sinus node and AV conducting tissue in all six hearts. Important ultrastructural alterations were inflammatory cell infiltrates and significant injury of specialized cells and of neural tissue. Specialized cells showed various features of degeneration and necrosis. Neural tissue damage included degeneration of axons and Schwann cells and disorganization of the neuromuscular junctions. Inflammatory cells, particularly macrophages, were often in intimate contact with injured specialized cells and neural tissue. Interstitial edema and bleeding and lymphatic vessel dilatation were also observed. These pathologic changes are considered to play an important role in the development of the documented disturbances of rhythm and conduction." @default.
• W1992511140 created "2016-06-24" @default.
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• W1992511140 date "1992-02-01" @default.
• W1992511140 modified "2023-10-03" @default.
• W1992511140 title "Ultrastructural alterations of the conduction system in mice exhibiting sinus arrest or heart block during coxsackievirus B3 acute myocarditis" @default.
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• W1992511140 doi "https://doi.org/10.1016/0002-8703(92)90659-j" @default.
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