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• W1992511689 endingPage "112" @default.
• W1992511689 startingPage "104" @default.
• W1992511689 abstract "B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has been instrumental to the discovery and functional characterization of human B-cell populations. Moreover, many events regulating B-cell development, activation, and effector functions are orchestrated by these cell-surface molecules. During the Ninth HLDA Workshop (HLDA9) eighteen new CDs were allocated to cell-surface molecules expressed on B cells: CD210a (IL10RA), CD215 (IL15RA), CD270 (TNFRSF14), CD307a (FCRL1), CD307b (FCRL2), CD307c (FCRL3), CD307d (FCRL4), CD351 (FCAMR), CD352 (SLAMF6), CD353 (SLAMF8), CD354 (TREM1), CD355 (CRTAM), CD357 (TNFRSF18), CD358 (TNFRSF21), CD360 (IL21RA), CD361 (EVI2B), CD362 (SDC2), and CD363 (S1PR1). Here we present their expression patterns on leukocytes, including T lymphocytes, NK cells, granulocytes, monocytes, plasmacytoid and monocyte-derived dendritic cells, and several B-cell subsets. These new CD molecules are expressed on B cells at various stages of differentiation; from bone marrow precursor pro-B cells to plasma cells. Three of them, CD307a, CD307b and CD307d, exhibit a B-cell restricted expression pattern, whereas the rest are also present on other leukocytes. In this paper we also review the structural characteristics, expression, and function of these new CD molecules. The availability of monoclonal antibodies directed against novel B cell-surface molecules will have broad implications not only for B-cell biology, but also for the development of new diagnostic and therapeutic tools." @default.
• W1992511689 created "2016-06-24" @default.
• W1992511689 creator A5009996665 @default.
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• W1992511689 creator A5071583658 @default.
• W1992511689 creator A5073496723 @default.
• W1992511689 creator A5087395078 @default.
• W1992511689 date "2011-01-30" @default.
• W1992511689 modified "2023-09-25" @default.
• W1992511689 title "New B-cell CD molecules" @default.
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• W1992511689 doi "https://doi.org/10.1016/j.imlet.2010.09.019" @default.
• W1992511689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20933010" @default.

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