Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992512706> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1992512706 endingPage "155" @default.
- W1992512706 startingPage "143" @default.
- W1992512706 abstract "To investigate the role of neuron-target interactions in regulating the survival of developing septo-hippocampal cholinergic neurons, hippocampal neurons were excitotoxically ablated in early postnatal rats. Four weeks after hippocampal ablation, hippocampal levels of brain-derived neurotrophic factor and nerve growth factor (NGF) mRNA had fallen to 15% of control values, and ipsilateral septal levels of NGF protein had fallen to 45% of control values. Four weeks after hippocampal ablation, the number of immunoreactive septal cholinergic neurons had fallen to 30% of control values. The number of cholinergic neurons in the septum correlated significantly with the amount of hippocampal tissue present. Ultrastructural analysis of the septal region at 3 days after hippocampal ablation showed no evidence of excitotoxic damage, but at 7 or 10 days showed degenerative profiles compatible with the delayed cell death of large septal neurons. Two weeks of NGF administration, initiated at 4 weeks after hippocampal lesions, failed to increase the number of detectable cholinergic neurons in the septal region, suggesting that the loss of immunoreactive neurons seen at 4 weeks represented cell death rather than downregulation of cholinergic markers. These findings suggest that septal cholinergic neurons depend for survival during early postnatal development on interactions with hippocampal neurons and are compatible with the possibility that neurotrophins play a role these interactions." @default.
- W1992512706 created "2016-06-24" @default.
- W1992512706 creator A5004141688 @default.
- W1992512706 creator A5011858801 @default.
- W1992512706 creator A5047430354 @default.
- W1992512706 creator A5058229542 @default.
- W1992512706 creator A5063007313 @default.
- W1992512706 date "1996-05-01" @default.
- W1992512706 modified "2023-10-18" @default.
- W1992512706 title "Delayed Death of Septal Cholinergic Neurons after Excitotoxic Ablation of Hippocampal Neurons during Early Postnatal Development in the Rat" @default.
- W1992512706 doi "https://doi.org/10.1006/exnr.1996.0089" @default.
- W1992512706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8635561" @default.
- W1992512706 hasPublicationYear "1996" @default.
- W1992512706 type Work @default.
- W1992512706 sameAs 1992512706 @default.
- W1992512706 citedByCount "30" @default.
- W1992512706 countsByYear W19925127062012 @default.
- W1992512706 countsByYear W19925127062013 @default.
- W1992512706 countsByYear W19925127062014 @default.
- W1992512706 countsByYear W19925127062015 @default.
- W1992512706 countsByYear W19925127062016 @default.
- W1992512706 countsByYear W19925127062017 @default.
- W1992512706 crossrefType "journal-article" @default.
- W1992512706 hasAuthorship W1992512706A5004141688 @default.
- W1992512706 hasAuthorship W1992512706A5011858801 @default.
- W1992512706 hasAuthorship W1992512706A5047430354 @default.
- W1992512706 hasAuthorship W1992512706A5058229542 @default.
- W1992512706 hasAuthorship W1992512706A5063007313 @default.
- W1992512706 hasConcept C104966671 @default.
- W1992512706 hasConcept C126322002 @default.
- W1992512706 hasConcept C134018914 @default.
- W1992512706 hasConcept C148762608 @default.
- W1992512706 hasConcept C160539049 @default.
- W1992512706 hasConcept C169760540 @default.
- W1992512706 hasConcept C170493617 @default.
- W1992512706 hasConcept C22885893 @default.
- W1992512706 hasConcept C2778423431 @default.
- W1992512706 hasConcept C2778794669 @default.
- W1992512706 hasConcept C2781161787 @default.
- W1992512706 hasConcept C2910204272 @default.
- W1992512706 hasConcept C71924100 @default.
- W1992512706 hasConcept C86803240 @default.
- W1992512706 hasConcept C92020748 @default.
- W1992512706 hasConceptScore W1992512706C104966671 @default.
- W1992512706 hasConceptScore W1992512706C126322002 @default.
- W1992512706 hasConceptScore W1992512706C134018914 @default.
- W1992512706 hasConceptScore W1992512706C148762608 @default.
- W1992512706 hasConceptScore W1992512706C160539049 @default.
- W1992512706 hasConceptScore W1992512706C169760540 @default.
- W1992512706 hasConceptScore W1992512706C170493617 @default.
- W1992512706 hasConceptScore W1992512706C22885893 @default.
- W1992512706 hasConceptScore W1992512706C2778423431 @default.
- W1992512706 hasConceptScore W1992512706C2778794669 @default.
- W1992512706 hasConceptScore W1992512706C2781161787 @default.
- W1992512706 hasConceptScore W1992512706C2910204272 @default.
- W1992512706 hasConceptScore W1992512706C71924100 @default.
- W1992512706 hasConceptScore W1992512706C86803240 @default.
- W1992512706 hasConceptScore W1992512706C92020748 @default.
- W1992512706 hasIssue "1" @default.
- W1992512706 hasLocation W19925127061 @default.
- W1992512706 hasLocation W19925127062 @default.
- W1992512706 hasOpenAccess W1992512706 @default.
- W1992512706 hasPrimaryLocation W19925127061 @default.
- W1992512706 hasRelatedWork W1680194521 @default.
- W1992512706 hasRelatedWork W1965912928 @default.
- W1992512706 hasRelatedWork W1992512706 @default.
- W1992512706 hasRelatedWork W2002443683 @default.
- W1992512706 hasRelatedWork W2014153425 @default.
- W1992512706 hasRelatedWork W2069958148 @default.
- W1992512706 hasRelatedWork W2072994984 @default.
- W1992512706 hasRelatedWork W2088479689 @default.
- W1992512706 hasRelatedWork W2413878691 @default.
- W1992512706 hasRelatedWork W2528593817 @default.
- W1992512706 hasVolume "139" @default.
- W1992512706 isParatext "false" @default.
- W1992512706 isRetracted "false" @default.
- W1992512706 magId "1992512706" @default.
- W1992512706 workType "article" @default.