Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992515297> ?p ?o ?g. }
- W1992515297 endingPage "979" @default.
- W1992515297 startingPage "975" @default.
- W1992515297 abstract "Haptoglobin (Hp) and ceruloplasmin (CP) are 2 plasma antioxidants playing a role in preventing iron-induced oxidative damage. This study presents data related to Hp phenotypes and ceruloplasmin ferroxidase activity in relation to iron store markers in patients with β-thalassemia major.Blood specimens were collected from 196 subjects (124 β-thalassemia major patients and 72 healthy controls). Serum levels of iron, total iron binding capacity (TIBC), ferritin, high sensitivity C-reactive protein (hs-CRP), ceruloplasmin, and ferroxidase activity were determined using conventional methods. Haptoglobin phenotypes were determined by polyacrylamide gel electrophoresis.As expected, the mean levels of iron store markers, except TIBC, were significantly higher in patients than in controls. Ceruloplasmin concentrations (mg/dl) and its ferroxidase activity (U/l) were significantly higher in patients than in controls (57.9±18.8 vs 46.9±14.2 and 159.9±47.8 vs 95.3±20.9; p<0.001, for CP and Hp, respectively). As for Hp phenotypes, no significant differences were observed between iron store markers and ferroxidase activity among the control group. In the patients group however, significantly higher concentrations of ceruloplasmin and its ferroxidase activity were observed among patients with Hp2-2 phenotype as compared to patients with the other phenotypes. Additionally, correlations according to Hp phenotypes revealed strong association between ceruloplasmin ferroxidase activity and serum ferritin in patients with Hp 2-2 phenotype and not in the others (r=0.331, p<0.05).Thalassemia patients with Hp 2-2 phenotype are under greater iron-driven oxidative stress than patients with other phenotypes." @default.
- W1992515297 created "2016-06-24" @default.
- W1992515297 creator A5023150836 @default.
- W1992515297 creator A5041005435 @default.
- W1992515297 creator A5065051913 @default.
- W1992515297 creator A5090785554 @default.
- W1992515297 date "2011-05-01" @default.
- W1992515297 modified "2023-10-17" @default.
- W1992515297 title "Association of haptoglobin phenotypes with ceruloplasmin ferroxidase activity in β-thalassemia major" @default.
- W1992515297 cites W1535567348 @default.
- W1992515297 cites W1580665972 @default.
- W1992515297 cites W1924338526 @default.
- W1992515297 cites W1926159205 @default.
- W1992515297 cites W1952998156 @default.
- W1992515297 cites W1970096539 @default.
- W1992515297 cites W1972744280 @default.
- W1992515297 cites W1981525286 @default.
- W1992515297 cites W1983800043 @default.
- W1992515297 cites W1993916376 @default.
- W1992515297 cites W1997531635 @default.
- W1992515297 cites W2007619249 @default.
- W1992515297 cites W2030607389 @default.
- W1992515297 cites W2033392675 @default.
- W1992515297 cites W2036615604 @default.
- W1992515297 cites W2045147282 @default.
- W1992515297 cites W2056149198 @default.
- W1992515297 cites W2060432333 @default.
- W1992515297 cites W2067672885 @default.
- W1992515297 cites W2068337287 @default.
- W1992515297 cites W2070771807 @default.
- W1992515297 cites W2078904403 @default.
- W1992515297 cites W2080766013 @default.
- W1992515297 cites W2084024242 @default.
- W1992515297 cites W2090175997 @default.
- W1992515297 cites W2092807733 @default.
- W1992515297 cites W2102055346 @default.
- W1992515297 cites W2104657893 @default.
- W1992515297 cites W2118156785 @default.
- W1992515297 cites W2134004059 @default.
- W1992515297 cites W2142473051 @default.
- W1992515297 cites W2164156793 @default.
- W1992515297 cites W2221055924 @default.
- W1992515297 cites W2748779067 @default.
- W1992515297 cites W70287413 @default.
- W1992515297 doi "https://doi.org/10.1016/j.cca.2011.02.003" @default.
- W1992515297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21315066" @default.
- W1992515297 hasPublicationYear "2011" @default.
- W1992515297 type Work @default.
- W1992515297 sameAs 1992515297 @default.
- W1992515297 citedByCount "9" @default.
- W1992515297 countsByYear W19925152972012 @default.
- W1992515297 countsByYear W19925152972013 @default.
- W1992515297 countsByYear W19925152972014 @default.
- W1992515297 countsByYear W19925152972015 @default.
- W1992515297 countsByYear W19925152972018 @default.
- W1992515297 countsByYear W19925152972023 @default.
- W1992515297 crossrefType "journal-article" @default.
- W1992515297 hasAuthorship W1992515297A5023150836 @default.
- W1992515297 hasAuthorship W1992515297A5041005435 @default.
- W1992515297 hasAuthorship W1992515297A5065051913 @default.
- W1992515297 hasAuthorship W1992515297A5090785554 @default.
- W1992515297 hasConcept C104317684 @default.
- W1992515297 hasConcept C126322002 @default.
- W1992515297 hasConcept C127716648 @default.
- W1992515297 hasConcept C134018914 @default.
- W1992515297 hasConcept C185592680 @default.
- W1992515297 hasConcept C206396517 @default.
- W1992515297 hasConcept C2777799968 @default.
- W1992515297 hasConcept C2778319317 @default.
- W1992515297 hasConcept C2778917026 @default.
- W1992515297 hasConcept C28452662 @default.
- W1992515297 hasConcept C55493867 @default.
- W1992515297 hasConcept C71924100 @default.
- W1992515297 hasConcept C86803240 @default.
- W1992515297 hasConceptScore W1992515297C104317684 @default.
- W1992515297 hasConceptScore W1992515297C126322002 @default.
- W1992515297 hasConceptScore W1992515297C127716648 @default.
- W1992515297 hasConceptScore W1992515297C134018914 @default.
- W1992515297 hasConceptScore W1992515297C185592680 @default.
- W1992515297 hasConceptScore W1992515297C206396517 @default.
- W1992515297 hasConceptScore W1992515297C2777799968 @default.
- W1992515297 hasConceptScore W1992515297C2778319317 @default.
- W1992515297 hasConceptScore W1992515297C2778917026 @default.
- W1992515297 hasConceptScore W1992515297C28452662 @default.
- W1992515297 hasConceptScore W1992515297C55493867 @default.
- W1992515297 hasConceptScore W1992515297C71924100 @default.
- W1992515297 hasConceptScore W1992515297C86803240 @default.
- W1992515297 hasIssue "11-12" @default.
- W1992515297 hasLocation W19925152971 @default.
- W1992515297 hasLocation W19925152972 @default.
- W1992515297 hasOpenAccess W1992515297 @default.
- W1992515297 hasPrimaryLocation W19925152971 @default.
- W1992515297 hasRelatedWork W1669435609 @default.
- W1992515297 hasRelatedWork W1992515297 @default.
- W1992515297 hasRelatedWork W1994708657 @default.
- W1992515297 hasRelatedWork W2028704923 @default.
- W1992515297 hasRelatedWork W2063240950 @default.
- W1992515297 hasRelatedWork W2116081441 @default.