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• W1992532640 abstract "Biochemical and behavioural experiments have indicated that the novel antidepressant tianeptine stimulates 5-hydroxytryptamine (5-HT) reuptake. The present study has explored the influence of acute tianeptine pretreatment upon corticosterone release and body weight loss following l-5-hydroxytryptophan (5-HTP) administration in conscious rats. Administration of 5-HTP (20 mg/kg i.v.) increased plasma corticosterone levels to a similar extent in rats pretreated either with saline or tianeptine (10 mg/kg i.p., 60 min beforehand). Besides, prior administration of benserazide (50 mg/kg i.p., 30 min beforehand), an inhibitor of peripheral aromatic l-amino acid decarboxylase, prevented 5-HTP-induced corticosterone release in both saline- and tianeptine-pretreated rats. However, combined administration of benserazidee and 5-HTP decreased overnight body weight in saline-, but not in tianeptine-pretreated rats. These results suggest that tianeptine preferentially activates 5-HT reuptake in central serotonergic neurones." @default.
• W1992532640 created "2016-06-24" @default.
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• W1992532640 date "1992-06-01" @default.
• W1992532640 modified "2023-09-25" @default.
• W1992532640 title "Differential effects of the novel antidepressant tianeptine on l-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss" @default.
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• W1992532640 doi "https://doi.org/10.1016/0924-977x(92)90020-9" @default.
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