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- W1992533419 abstract "The novel type I TGFbeta family member receptor alk8 is expressed both maternally and zygotically. Functional characterization of alk8 was performed using microinjection studies of constitutively active (CA), kinase modified/dominant negative (DN), and truncated alk8 mRNAs. CA Alk8 expression produces ventralized embryos while DN Alk8 expression results in dorsalized phenotypes. Truncated alk8 expressing embryos display a subtle dorsalized phenotype closely resembling that of the identified zebrafish dorsalized mutant, lost-a-fin (laf). Single-strand conformation polymorphism (SSCP) analysis was used to map alk8 to zebrafish LG02 in a region demonstrating significant conserved synteny to Hsa2, and which contains the human alk2 gene, ACVRI. Altogether, these functional, gene mapping and phylogenetic analyses suggest that alk8 may be the zebrafish orthologue to human ACVRI (alk2), and therefore extend previous studies of Alk2 conducted in Xenopus." @default.
- W1992533419 created "2016-06-24" @default.
- W1992533419 creator A5048989359 @default.
- W1992533419 creator A5068312032 @default.
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- W1992533419 date "2001-02-01" @default.
- W1992533419 modified "2023-10-09" @default.
- W1992533419 title "Functional characterization and genetic mapping of alk8" @default.
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- W1992533419 doi "https://doi.org/10.1016/s0925-4773(00)00541-4" @default.
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