FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992536259> ?p ?o ?g. }

• W1992536259 endingPage "926" @default.
• W1992536259 startingPage "919" @default.
• W1992536259 abstract "The metabolism of doxorubicin (A) 4′-epidoxorubicin (E) and 4′-deoxydoxorubicin (D) was studied in vitro by incubating the analogs with rat liver subcellular fractions and in vivo by chromatographic analysis of human urine. Metabolites were identified by high-pressure liquid chromatography, fluorescence spectroscopy and enzymatic conversion. Human urine contained unchanged drug as well as the corresponding alcohol metabolites in all cases; however, urine of patients who received E also contained two glucuronides which could not be detected in the urine of patients who received A or D. We have identified these glucuronides as 4′-epidoxorubicin glucuronide (E-Glu) and 4′-epidoxorubicinol glucuronide (Eol-Glu). It was concluded that the glucuronide moiety is linked to the daunosamine sugar at the C4′-OH position. A hypothesis is proposed that this glucuronidation pathway may explain the differences in pharmacokinetics and toxicity between E and A. Rat liver microsomes were found to convert all three drugs to the 7-deoxyaglycones at the same rate. Rat liver 100,000 g supernatant was found to be capable of converting these drugs to their respective alcohol metabolites, doxorubicinol (Aol) being formed somewhat slower than 4′-epidoxorubicinol (Eol) and 4′-deoxydoxorubicinol (Dol)." @default.
• W1992536259 created "2016-06-24" @default.
• W1992536259 creator A5021686227 @default.
• W1992536259 creator A5054018757 @default.
• W1992536259 creator A5054139936 @default.
• W1992536259 creator A5062035206 @default.
• W1992536259 creator A5076675999 @default.
• W1992536259 date "1984-07-01" @default.
• W1992536259 modified "2023-10-03" @default.
• W1992536259 title "Metabolism of 4′-modified analogs of doxorubicin. Unique glucuronidation pathway for 4′-epidoxorubicin" @default.
• W1992536259 cites W1487196255 @default.
• W1992536259 cites W1808637054 @default.
• W1992536259 cites W1985268300 @default.
• W1992536259 cites W1992786087 @default.
• W1992536259 cites W1998973395 @default.
• W1992536259 cites W2005217234 @default.
• W1992536259 cites W2042525042 @default.
• W1992536259 cites W2103681475 @default.
• W1992536259 cites W2153156872 @default.
• W1992536259 cites W2235940902 @default.
• W1992536259 cites W2419673119 @default.
• W1992536259 cites W4293247451 @default.
• W1992536259 doi "https://doi.org/10.1016/0277-5379(84)90165-2" @default.
• W1992536259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6589165" @default.
• W1992536259 hasPublicationYear "1984" @default.
• W1992536259 type Work @default.
• W1992536259 sameAs 1992536259 @default.
• W1992536259 citedByCount "65" @default.
• W1992536259 countsByYear W19925362592012 @default.
• W1992536259 countsByYear W19925362592013 @default.
• W1992536259 countsByYear W19925362592016 @default.
• W1992536259 countsByYear W19925362592017 @default.
• W1992536259 countsByYear W19925362592019 @default.
• W1992536259 countsByYear W19925362592021 @default.
• W1992536259 countsByYear W19925362592022 @default.
• W1992536259 countsByYear W19925362592023 @default.
• W1992536259 crossrefType "journal-article" @default.
• W1992536259 hasAuthorship W1992536259A5021686227 @default.
• W1992536259 hasAuthorship W1992536259A5054018757 @default.
• W1992536259 hasAuthorship W1992536259A5054139936 @default.
• W1992536259 hasAuthorship W1992536259A5062035206 @default.
• W1992536259 hasAuthorship W1992536259A5076675999 @default.
• W1992536259 hasBestOaLocation W19925362592 @default.
• W1992536259 hasConcept C112705442 @default.
• W1992536259 hasConcept C126322002 @default.
• W1992536259 hasConcept C150903083 @default.
• W1992536259 hasConcept C185592680 @default.
• W1992536259 hasConcept C202751555 @default.
• W1992536259 hasConcept C207001950 @default.
• W1992536259 hasConcept C2776694085 @default.
• W1992536259 hasConcept C2777477808 @default.
• W1992536259 hasConcept C2779186261 @default.
• W1992536259 hasConcept C2779907587 @default.
• W1992536259 hasConcept C2780026642 @default.
• W1992536259 hasConcept C2781066024 @default.
• W1992536259 hasConcept C2781303535 @default.
• W1992536259 hasConcept C43617362 @default.
• W1992536259 hasConcept C55493867 @default.
• W1992536259 hasConcept C62231903 @default.
• W1992536259 hasConcept C71924100 @default.
• W1992536259 hasConcept C86803240 @default.
• W1992536259 hasConcept C87644729 @default.
• W1992536259 hasConcept C98274493 @default.
• W1992536259 hasConceptScore W1992536259C112705442 @default.
• W1992536259 hasConceptScore W1992536259C126322002 @default.
• W1992536259 hasConceptScore W1992536259C150903083 @default.
• W1992536259 hasConceptScore W1992536259C185592680 @default.
• W1992536259 hasConceptScore W1992536259C202751555 @default.
• W1992536259 hasConceptScore W1992536259C207001950 @default.
• W1992536259 hasConceptScore W1992536259C2776694085 @default.
• W1992536259 hasConceptScore W1992536259C2777477808 @default.
• W1992536259 hasConceptScore W1992536259C2779186261 @default.
• W1992536259 hasConceptScore W1992536259C2779907587 @default.
• W1992536259 hasConceptScore W1992536259C2780026642 @default.
• W1992536259 hasConceptScore W1992536259C2781066024 @default.
• W1992536259 hasConceptScore W1992536259C2781303535 @default.
• W1992536259 hasConceptScore W1992536259C43617362 @default.
• W1992536259 hasConceptScore W1992536259C55493867 @default.
• W1992536259 hasConceptScore W1992536259C62231903 @default.
• W1992536259 hasConceptScore W1992536259C71924100 @default.
• W1992536259 hasConceptScore W1992536259C86803240 @default.
• W1992536259 hasConceptScore W1992536259C87644729 @default.
• W1992536259 hasConceptScore W1992536259C98274493 @default.
• W1992536259 hasIssue "7" @default.
• W1992536259 hasLocation W19925362591 @default.
• W1992536259 hasLocation W19925362592 @default.
• W1992536259 hasLocation W19925362593 @default.
• W1992536259 hasOpenAccess W1992536259 @default.
• W1992536259 hasPrimaryLocation W19925362591 @default.
• W1992536259 hasRelatedWork W2015484631 @default.
• W1992536259 hasRelatedWork W2027761686 @default.
• W1992536259 hasRelatedWork W2035747340 @default.
• W1992536259 hasRelatedWork W2040052389 @default.
• W1992536259 hasRelatedWork W2050115426 @default.
• W1992536259 hasRelatedWork W2098811551 @default.
• W1992536259 hasRelatedWork W2103681475 @default.
• W1992536259 hasRelatedWork W2114529847 @default.
• W1992536259 hasRelatedWork W2127130326 @default.

• next