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- W1992551317 endingPage "1201" @default.
- W1992551317 startingPage "1189" @default.
- W1992551317 abstract "Toxoplasma gondii is a leading cause of neurological birth defects and a serious opportunistic pathogen. The authors and others have found that Toxoplasma uses a unique nucleosome composition supporting a fine gene regulation together with other factors. Post-translational modifications in histones facilitate the establishment of a global chromatin environment and orchestrate DNA-related biological processes. Histone acetylation is one of the most prominent post-translational modifications influencing gene expression. Histone acetyltransferases and histone deacetylases have been intensively studied as potential drug targets. In particular, histone deacetylase inhibitors have activity against apicomplexan parasites, underscoring their potential as a new class of antiparasitic compounds. In this review, we summarize what is known about Toxoplasma histone acetyltransferases and histone deacetylases, and discuss the inhibitors studied to date. Finally, the authors discuss the distinct possibility that the unique nucleosome composition of Toxoplasma, which harbors a nonconserved H2Bv variant histone, might be targeted in novel therapeutics directed against this parasite." @default.
- W1992551317 created "2016-06-24" @default.
- W1992551317 creator A5025816215 @default.
- W1992551317 creator A5029428993 @default.
- W1992551317 creator A5045014537 @default.
- W1992551317 creator A5070173472 @default.
- W1992551317 creator A5075319830 @default.
- W1992551317 creator A5076556785 @default.
- W1992551317 date "2012-10-01" @default.
- W1992551317 modified "2023-10-10" @default.
- W1992551317 title "<i>Toxoplasma</i>histone acetylation remodelers as novel drug targets" @default.
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