FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992553088> ?p ?o ?g. }

• W1992553088 endingPage "751" @default.
• W1992553088 startingPage "741" @default.
• W1992553088 abstract "The in vitro and in vivo combination of oxaliplatin and irinotecan was investigated in a panel of four human colon cancer cell lines and their counterpart xenografts. In vitro and in vivo experiments demonstrated a synergistic or additive interaction in three cell lines (HCT-116, HCT-8 and HT-29) and an antagonism in SW-620 cells. Since there were clearly opposite interactions depending on the cell line, we further investigated cellular determinants possibly involved in the interaction between the two drugs in HCT-8 and SW-620 cells. Irinotecan slowed down the early platinum-DNA adducts repair (1 h after oxaliplatin exposure) in the presence of irinotecan only in HCT-8 cells (p=0.03, n=3). Moreover, a decrease of the expression of two proteins of the nucleotide excision repair (NER) system, ERCC1 and XPA, was observed. None of these effects was seen in SW-620 cells. Irinotecan induced apoptosis with an increase of poly(ADP-ribose) polymerase (PARP) cleavage in SW-620 cells (60 versus 7% basal level). Pretreatment of these cells with oxaliplatin abolished the increase in PARP cleavage induced by irinotecan (29%). In HCT-8 cells, a very little PARP cleavage was observed whatever the drug treatment. The persistence of platinum-DNA adducts in the presence of irinotecan could be due to a direct impact of irinotecan on NER gene expression or to an indirect effect on topoisomerase I activity. Complementary studies are required to determine if the cellular parameters identified in this study could be translated at the clinical level to predict clinical response after combined treatment with oxaliplatin and irinotecan in humans." @default.
• W1992553088 created "2016-06-24" @default.
• W1992553088 creator A5018514406 @default.
• W1992553088 creator A5040373927 @default.
• W1992553088 creator A5041701219 @default.
• W1992553088 creator A5043747827 @default.
• W1992553088 creator A5054847166 @default.
• W1992553088 date "2001-10-01" @default.
• W1992553088 modified "2023-10-11" @default.
• W1992553088 title "Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo" @default.
• W1992553088 cites W1912318374 @default.
• W1992553088 cites W1963528972 @default.
• W1992553088 cites W2003772907 @default.
• W1992553088 cites W2006824814 @default.
• W1992553088 cites W2015829835 @default.
• W1992553088 cites W2017739390 @default.
• W1992553088 cites W2018588892 @default.
• W1992553088 cites W2025007043 @default.
• W1992553088 cites W2028547579 @default.
• W1992553088 cites W2033281614 @default.
• W1992553088 cites W2043363330 @default.
• W1992553088 cites W2046022946 @default.
• W1992553088 cites W2053025410 @default.
• W1992553088 cites W2077945404 @default.
• W1992553088 cites W2087395461 @default.
• W1992553088 cites W2096122707 @default.
• W1992553088 cites W2109689528 @default.
• W1992553088 cites W2122731269 @default.
• W1992553088 cites W2156942788 @default.
• W1992553088 cites W4241956099 @default.
• W1992553088 doi "https://doi.org/10.1097/00001813-200110000-00006" @default.
• W1992553088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11593056" @default.
• W1992553088 hasPublicationYear "2001" @default.
• W1992553088 type Work @default.
• W1992553088 sameAs 1992553088 @default.
• W1992553088 citedByCount "37" @default.
• W1992553088 countsByYear W19925530882012 @default.
• W1992553088 countsByYear W19925530882013 @default.
• W1992553088 countsByYear W19925530882014 @default.
• W1992553088 countsByYear W19925530882016 @default.
• W1992553088 countsByYear W19925530882017 @default.
• W1992553088 countsByYear W19925530882018 @default.
• W1992553088 countsByYear W19925530882022 @default.
• W1992553088 crossrefType "journal-article" @default.
• W1992553088 hasAuthorship W1992553088A5018514406 @default.
• W1992553088 hasAuthorship W1992553088A5040373927 @default.
• W1992553088 hasAuthorship W1992553088A5041701219 @default.
• W1992553088 hasAuthorship W1992553088A5043747827 @default.
• W1992553088 hasAuthorship W1992553088A5054847166 @default.
• W1992553088 hasConcept C104451858 @default.
• W1992553088 hasConcept C121608353 @default.
• W1992553088 hasConcept C134935766 @default.
• W1992553088 hasConcept C143425029 @default.
• W1992553088 hasConcept C147897179 @default.
• W1992553088 hasConcept C153911025 @default.
• W1992553088 hasConcept C182979987 @default.
• W1992553088 hasConcept C185592680 @default.
• W1992553088 hasConcept C190283241 @default.
• W1992553088 hasConcept C202751555 @default.
• W1992553088 hasConcept C207001950 @default.
• W1992553088 hasConcept C2779309665 @default.
• W1992553088 hasConcept C2779682216 @default.
• W1992553088 hasConcept C2780259306 @default.
• W1992553088 hasConcept C2780962732 @default.
• W1992553088 hasConcept C502942594 @default.
• W1992553088 hasConcept C526805850 @default.
• W1992553088 hasConcept C54355233 @default.
• W1992553088 hasConcept C552990157 @default.
• W1992553088 hasConcept C55493867 @default.
• W1992553088 hasConcept C81885089 @default.
• W1992553088 hasConcept C82381507 @default.
• W1992553088 hasConcept C86803240 @default.
• W1992553088 hasConcept C98274493 @default.
• W1992553088 hasConceptScore W1992553088C104451858 @default.
• W1992553088 hasConceptScore W1992553088C121608353 @default.
• W1992553088 hasConceptScore W1992553088C134935766 @default.
• W1992553088 hasConceptScore W1992553088C143425029 @default.
• W1992553088 hasConceptScore W1992553088C147897179 @default.
• W1992553088 hasConceptScore W1992553088C153911025 @default.
• W1992553088 hasConceptScore W1992553088C182979987 @default.
• W1992553088 hasConceptScore W1992553088C185592680 @default.
• W1992553088 hasConceptScore W1992553088C190283241 @default.
• W1992553088 hasConceptScore W1992553088C202751555 @default.
• W1992553088 hasConceptScore W1992553088C207001950 @default.
• W1992553088 hasConceptScore W1992553088C2779309665 @default.
• W1992553088 hasConceptScore W1992553088C2779682216 @default.
• W1992553088 hasConceptScore W1992553088C2780259306 @default.
• W1992553088 hasConceptScore W1992553088C2780962732 @default.
• W1992553088 hasConceptScore W1992553088C502942594 @default.
• W1992553088 hasConceptScore W1992553088C526805850 @default.
• W1992553088 hasConceptScore W1992553088C54355233 @default.
• W1992553088 hasConceptScore W1992553088C552990157 @default.
• W1992553088 hasConceptScore W1992553088C55493867 @default.
• W1992553088 hasConceptScore W1992553088C81885089 @default.
• W1992553088 hasConceptScore W1992553088C82381507 @default.
• W1992553088 hasConceptScore W1992553088C86803240 @default.
• W1992553088 hasConceptScore W1992553088C98274493 @default.
• W1992553088 hasIssue "9" @default.

• next