Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992558528> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1992558528 endingPage "1068" @default.
- W1992558528 startingPage "1061" @default.
- W1992558528 abstract "To describe our 3-dimensional conformal planning approaches and report early toxicities with stereotactic body radiation therapy for the management of primary renal cell carcinoma.This is an analysis of a phase 1 trial of stereotactic body radiation therapy for primary inoperable renal cell carcinoma. A dose of 42 Gy/3 fractions was prescribed to targets ≥5 cm, whereas for <5 cm 26 Gy/1 fraction was used. All patients underwent a planning 4-dimensional CT to generate a planning target volume (PTV) from a 5-mm isotropic expansion of the internal target volume. Planning required a minimum of 8 fields prescribing to the minimum isodose surrounding the PTV. Intermediate dose spillage at 50% of the prescription dose (R50%) was measured to describe the dose gradient. Early toxicity (<6 months) was scored using the Common Terminology Criteria for Adverse Events (v4.0).From July 2012 to August 2013 a total of 20 patients (median age, 77 years) were recruited into a prospective clinical trial. Eleven patients underwent fractionated treatment and 9 patients a single fraction. For PTV targets <100 cm(3) the median number of beams used was 8 (2 noncoplanar) to achieve an average R50% of 3.7. For PTV targets >100 cm(3) the median beam number used was 10 (4 noncoplanar) for an average R50% value of 4.3. The R50% was inversely proportional to decreasing PTV volume (r=-0.62, P=.003) and increasing total beams used (r=-0.51, P=.022). Twelve of 20 patients (60%) suffered grade ≤2 early toxicity, whereas 8 of 20 patients (40%) were asymptomatic. Nausea, chest wall pain, and fatigue were the most common toxicities reported.A 3-dimensional conformal planning technique of 8-10 beams can be used to deliver highly tolerable stereotactic ablation to primary kidney targets with minimal early toxicities. Ongoing follow-up is currently in place to assess long-term toxicities and cancer control." @default.
- W1992558528 created "2016-06-24" @default.
- W1992558528 creator A5009917580 @default.
- W1992558528 creator A5031780293 @default.
- W1992558528 creator A5038831861 @default.
- W1992558528 creator A5042620193 @default.
- W1992558528 creator A5051245904 @default.
- W1992558528 creator A5069457274 @default.
- W1992558528 creator A5079329522 @default.
- W1992558528 creator A5083886265 @default.
- W1992558528 date "2014-12-01" @default.
- W1992558528 modified "2023-10-13" @default.
- W1992558528 title "Stereotactic Ablative Body Radiation Therapy for Primary Kidney Cancer: A 3-Dimensional Conformal Technique Associated With Low Rates of Early Toxicity" @default.
- W1992558528 cites W1529517881 @default.
- W1992558528 cites W1982864028 @default.
- W1992558528 cites W1985541438 @default.
- W1992558528 cites W1988227725 @default.
- W1992558528 cites W2015117534 @default.
- W1992558528 cites W2020870950 @default.
- W1992558528 cites W2030326542 @default.
- W1992558528 cites W2034365985 @default.
- W1992558528 cites W2063765581 @default.
- W1992558528 cites W2065849429 @default.
- W1992558528 cites W2078251238 @default.
- W1992558528 cites W2087887230 @default.
- W1992558528 cites W2105769194 @default.
- W1992558528 cites W2117234015 @default.
- W1992558528 cites W2136706275 @default.
- W1992558528 cites W2137867151 @default.
- W1992558528 cites W2140057952 @default.
- W1992558528 cites W2162427240 @default.
- W1992558528 cites W2170366300 @default.
- W1992558528 doi "https://doi.org/10.1016/j.ijrobp.2014.07.043" @default.
- W1992558528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25442039" @default.
- W1992558528 hasPublicationYear "2014" @default.
- W1992558528 type Work @default.
- W1992558528 sameAs 1992558528 @default.
- W1992558528 citedByCount "51" @default.
- W1992558528 countsByYear W19925585282014 @default.
- W1992558528 countsByYear W19925585282015 @default.
- W1992558528 countsByYear W19925585282016 @default.
- W1992558528 countsByYear W19925585282017 @default.
- W1992558528 countsByYear W19925585282018 @default.
- W1992558528 countsByYear W19925585282019 @default.
- W1992558528 countsByYear W19925585282020 @default.
- W1992558528 countsByYear W19925585282021 @default.
- W1992558528 countsByYear W19925585282022 @default.
- W1992558528 countsByYear W19925585282023 @default.
- W1992558528 crossrefType "journal-article" @default.
- W1992558528 hasAuthorship W1992558528A5009917580 @default.
- W1992558528 hasAuthorship W1992558528A5031780293 @default.
- W1992558528 hasAuthorship W1992558528A5038831861 @default.
- W1992558528 hasAuthorship W1992558528A5042620193 @default.
- W1992558528 hasAuthorship W1992558528A5051245904 @default.
- W1992558528 hasAuthorship W1992558528A5069457274 @default.
- W1992558528 hasAuthorship W1992558528A5079329522 @default.
- W1992558528 hasAuthorship W1992558528A5083886265 @default.
- W1992558528 hasConcept C126322002 @default.
- W1992558528 hasConcept C126838900 @default.
- W1992558528 hasConcept C155806632 @default.
- W1992558528 hasConcept C201645570 @default.
- W1992558528 hasConcept C2777472916 @default.
- W1992558528 hasConcept C2777793932 @default.
- W1992558528 hasConcept C29730261 @default.
- W1992558528 hasConcept C2989005 @default.
- W1992558528 hasConcept C509974204 @default.
- W1992558528 hasConcept C71924100 @default.
- W1992558528 hasConceptScore W1992558528C126322002 @default.
- W1992558528 hasConceptScore W1992558528C126838900 @default.
- W1992558528 hasConceptScore W1992558528C155806632 @default.
- W1992558528 hasConceptScore W1992558528C201645570 @default.
- W1992558528 hasConceptScore W1992558528C2777472916 @default.
- W1992558528 hasConceptScore W1992558528C2777793932 @default.
- W1992558528 hasConceptScore W1992558528C29730261 @default.
- W1992558528 hasConceptScore W1992558528C2989005 @default.
- W1992558528 hasConceptScore W1992558528C509974204 @default.
- W1992558528 hasConceptScore W1992558528C71924100 @default.
- W1992558528 hasIssue "5" @default.
- W1992558528 hasLocation W19925585281 @default.
- W1992558528 hasLocation W19925585282 @default.
- W1992558528 hasOpenAccess W1992558528 @default.
- W1992558528 hasPrimaryLocation W19925585281 @default.
- W1992558528 hasRelatedWork W2110043256 @default.
- W1992558528 hasRelatedWork W2126053364 @default.
- W1992558528 hasRelatedWork W2130930617 @default.
- W1992558528 hasRelatedWork W2380317881 @default.
- W1992558528 hasRelatedWork W2559241868 @default.
- W1992558528 hasRelatedWork W2805686800 @default.
- W1992558528 hasRelatedWork W3095751437 @default.
- W1992558528 hasRelatedWork W4229488205 @default.
- W1992558528 hasRelatedWork W4361027262 @default.
- W1992558528 hasRelatedWork W4387207905 @default.
- W1992558528 hasVolume "90" @default.
- W1992558528 isParatext "false" @default.
- W1992558528 isRetracted "false" @default.
- W1992558528 magId "1992558528" @default.
- W1992558528 workType "article" @default.