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• W1992563499 abstract "To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA + DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake. We cross-sectionally studied 3383 Japanese local government workers aged 35–66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA + DHA intake as the reference were calculated by logistic regression analysis. Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA + DHA were 47.9 years, 22.9 kg/m2, and 1.90 g/day (0.88%E) and 0.77 g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1 = 0.74, P for trend = 0.01) and the association was observed only in subjects with a BMI of < 25 kg/m2 (P for interaction = 0.033). However EPA + DHA showed no such associations consistently. Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women." @default.
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• W1992563499 date "2010-05-01" @default.
• W1992563499 modified "2023-09-30" @default.
• W1992563499 title "Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese" @default.
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• W1992563499 doi "https://doi.org/10.1016/j.ypmed.2010.02.014" @default.
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