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- W1992566153 abstract "Cartilage degeneration is the major hallmark of osteoarthritis. The repair and renewal capacity of articular cartilage has long been thought to be extremely limited. However, recent evidence for endogenous cartilage repair has cast doubt on this dogma. I will review recent literature on this process, the molecular mechanisms involved, and potential factors influencing renewal capacity (age, genetic background etc.). I will also focus on the pathways regulating development of articular cartilage, with the underlying working model that manipulation of these pathways is a promising strategy to promote growth and repair of articular cartilage. In this context I will present our recent data showing that cartilage-specific inactivation of the signaling molecule Mig-6 in mice results in marked increases in articular cartilage thickness and articular chondrocyte proliferation." @default.
- W1992566153 created "2016-06-24" @default.
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- W1992566153 date "2015-04-01" @default.
- W1992566153 modified "2023-09-29" @default.
- W1992566153 title "Endogenous mechanisms and pathways of cartilage healing" @default.
- W1992566153 doi "https://doi.org/10.1016/j.joca.2015.02.038" @default.
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