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- W1992578052 abstract "Benzimidazole derivatives 1-24 have been synthesized and their in vitro β-glucuronidase inhibitory activitiy was evaluated. Compounds 15 (IC50=6.33+/-0.40 μM), 7 (IC50=22.0+/-0.33 μM), 2 (IC50=23.1+/-1.78 μM), 17 (IC50=23.9+/-1.46 μM), and 3 (IC50=33.8+/-1.61 μM) showed more potent β-glucuronidase inhibitory activity than the standard (D-saccharic acid 1,4 lactone, IC50=48.4+/-1.25 μM). This study has identified a new series of potential β-glucuronidase inhibitors. A structure-activity relationship has also been studied." @default.
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- W1992578052 date "2012-05-01" @default.
- W1992578052 modified "2023-10-01" @default.
- W1992578052 title "Synthesis and β-Glucuronidase Inhibitory Potential of Benzimidazole Derivatives" @default.
- W1992578052 doi "https://doi.org/10.2174/1573406411208030421" @default.
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