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• W1992581857 abstract "The synthesis and the biological properties of orally active cephalosporin esters are described. 3-Methoxymethyl cephem derivatives having a 2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamide function at C-7 (1) showed good activity against a wide variety of bacteria including some β-lactamase producing species. The prodrug type esters of 1 exhibited a good urinary recovery after oral administration to mice and l-(isopropoxycarbonyloxy)ethyl ester (2a, CS-807) has been pre-clinically tested as an orally active cephem prodrug." @default.
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• W1992581857 date "1987-01-01" @default.
• W1992581857 modified "2023-10-15" @default.
• W1992581857 title "Studies on orally active cephalosporin esters." @default.
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• W1992581857 doi "https://doi.org/10.7164/antibiotics.40.370" @default.
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