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- W1992586278 abstract "Abstract Subcutaneous injections of 1 mg/kg isoproterenol HCl on 2 consecutive days to adult beagles of either sex induced necrosis in the left ventricle. Ventricular extrasystoles were recorded 24 hr after dosing. The same treatment repeated at intervals of 1, 2, and 7 wk induced necrosis but no extrasystoles. In dogs dosed every second week for 1 mo and weekly thereafter for 4 wk, no evidence of necrosis was found other than scarring. Extrasystoles were not detected. Necrosis was induced in adult Sherman rats after the sc injection of 1 mg/kg isoproterenol HCl on 2 consecutive days. The same treatment, repeated 2 wk later, failed to induce a lesion; however, when the interval was increased to 11 wk, necrosis was induced. Administration of 0.5 mg/kg isoproterenol on 2 consecutive days also induced necrosis, which was not evident in animals that received a similar daily dosing for 2 wk. Since isoproterenol induced the lesion by its exaggerated pharmacologic effect which manifested itself each time, the transitory resistance to its ischemic necrotizing effect must be sought in a transitory adaptive change in the myocardium." @default.
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- W1992586278 date "1972-02-01" @default.
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- W1992586278 title "The development of resistance to the ischemic cardiopathic effect of isoproterenol" @default.
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- W1992586278 doi "https://doi.org/10.1016/0041-008x(72)90063-4" @default.
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