FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992588369> ?p ?o ?g. }

• W1992588369 endingPage "69" @default.
• W1992588369 startingPage "63" @default.
• W1992588369 abstract "The authors have previously shown that duodenal adenomas in familial adenomatous polyposis (FAP) patients typically reveal abundant cells with endocrine differentiation (ED), Paneth differentiation (PD), and goblet cell differentiation (GD). However, the biological significance and proliferative potential of these cells is unknown. To study the proliferative properties of cells with ED, PD, or GD in FAP-associated duodenal adenomas, the authors used a double-labeling immunohistochemical technique to detect simultaneously the presence of proliferating cell nuclear antigen (PCNA), and either chromogranin or lysozyme in individual neoplastic cells. Adenomatous cells with GD were identified morphologically and also evaluated for the degree of PCNA expression by immunohistochemistry. Duodenal adenomas and the adjacent nonadenomatous epithelium from 10 FAP patients were studied. Cells with ED, PD, and GD were present in all adenomas, and constituted 14.1%, 11.6%, and 17.7% of adenomatous cells, respectively. The overall proliferative index of nondifferentiated adenomatous cells was 33.3%, which was similar to the proliferative index obtained for adenomatous cells with GD (31.2%) and nonadenomatous crypt goblet cells (34.9%). In contrast, adenomatous cells with ED and PD showed a significant decrease in their proliferative potential (P < .001). Only 6.0% and 7.3% of cells with ED and PD, respectively, were proliferative. Nonadenomatous crypt endocrine and Paneth cells showed no proliferative potential (proliferative index 0%). These results suggest that, in the process of proliferation and differentiation, specific subpopulations of adenomatous cells attempt to recapitulate the biological characteristics of their normal counterparts in the small intestinal crypts. Adenomatous cells with ED and PD are hypoproliferative, a finding that is consistent with their differentiated phenotype and suggests that these cells may not participate as actively in the growth of these lesions." @default.
• W1992588369 created "2016-06-24" @default.
• W1992588369 creator A5061079739 @default.
• W1992588369 creator A5080210254 @default.
• W1992588369 date "1996-01-01" @default.
• W1992588369 modified "2023-10-14" @default.
• W1992588369 title "Proliferative characteristics of differentiated cells in familial adenomatous polyposis-associated duodenal adenomas*1" @default.
• W1992588369 cites W1488944541 @default.
• W1992588369 cites W1493939367 @default.
• W1992588369 cites W1561804912 @default.
• W1992588369 cites W1963833350 @default.
• W1992588369 cites W1971598246 @default.
• W1992588369 cites W1985736378 @default.
• W1992588369 cites W199134432 @default.
• W1992588369 cites W2006626786 @default.
• W1992588369 cites W2007697171 @default.
• W1992588369 cites W2014987459 @default.
• W1992588369 cites W2018713713 @default.
• W1992588369 cites W2031162643 @default.
• W1992588369 cites W2036058666 @default.
• W1992588369 cites W2036070753 @default.
• W1992588369 cites W2037968512 @default.
• W1992588369 cites W2043061137 @default.
• W1992588369 cites W2043785963 @default.
• W1992588369 cites W2045643245 @default.
• W1992588369 cites W2055197016 @default.
• W1992588369 cites W2060089180 @default.
• W1992588369 cites W2060227425 @default.
• W1992588369 cites W2071230078 @default.
• W1992588369 cites W2073508367 @default.
• W1992588369 cites W2074015667 @default.
• W1992588369 cites W2080154945 @default.
• W1992588369 cites W2103635373 @default.
• W1992588369 cites W2160976490 @default.
• W1992588369 cites W2411906888 @default.
• W1992588369 cites W2415378719 @default.
• W1992588369 cites W2418355976 @default.
• W1992588369 cites W2426170976 @default.
• W1992588369 cites W274027041 @default.
• W1992588369 cites W47013338 @default.
• W1992588369 cites W562678055 @default.
• W1992588369 doi "https://doi.org/10.1016/s0046-8177(96)90139-2" @default.
• W1992588369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8543313" @default.
• W1992588369 hasPublicationYear "1996" @default.
• W1992588369 type Work @default.
• W1992588369 sameAs 1992588369 @default.
• W1992588369 citedByCount "4" @default.
• W1992588369 countsByYear W19925883692012 @default.
• W1992588369 countsByYear W19925883692014 @default.
• W1992588369 crossrefType "journal-article" @default.
• W1992588369 hasAuthorship W1992588369A5061079739 @default.
• W1992588369 hasAuthorship W1992588369A5080210254 @default.
• W1992588369 hasConcept C103395026 @default.
• W1992588369 hasConcept C104317684 @default.
• W1992588369 hasConcept C121608353 @default.
• W1992588369 hasConcept C126322002 @default.
• W1992588369 hasConcept C134018914 @default.
• W1992588369 hasConcept C142724271 @default.
• W1992588369 hasConcept C148738053 @default.
• W1992588369 hasConcept C204232928 @default.
• W1992588369 hasConcept C2778237340 @default.
• W1992588369 hasConcept C2780814781 @default.
• W1992588369 hasConcept C2910938049 @default.
• W1992588369 hasConcept C34688535 @default.
• W1992588369 hasConcept C46699223 @default.
• W1992588369 hasConcept C502942594 @default.
• W1992588369 hasConcept C526805850 @default.
• W1992588369 hasConcept C55493867 @default.
• W1992588369 hasConcept C66090201 @default.
• W1992588369 hasConcept C71315377 @default.
• W1992588369 hasConcept C71924100 @default.
• W1992588369 hasConcept C77231918 @default.
• W1992588369 hasConcept C86803240 @default.
• W1992588369 hasConceptScore W1992588369C103395026 @default.
• W1992588369 hasConceptScore W1992588369C104317684 @default.
• W1992588369 hasConceptScore W1992588369C121608353 @default.
• W1992588369 hasConceptScore W1992588369C126322002 @default.
• W1992588369 hasConceptScore W1992588369C134018914 @default.
• W1992588369 hasConceptScore W1992588369C142724271 @default.
• W1992588369 hasConceptScore W1992588369C148738053 @default.
• W1992588369 hasConceptScore W1992588369C204232928 @default.
• W1992588369 hasConceptScore W1992588369C2778237340 @default.
• W1992588369 hasConceptScore W1992588369C2780814781 @default.
• W1992588369 hasConceptScore W1992588369C2910938049 @default.
• W1992588369 hasConceptScore W1992588369C34688535 @default.
• W1992588369 hasConceptScore W1992588369C46699223 @default.
• W1992588369 hasConceptScore W1992588369C502942594 @default.
• W1992588369 hasConceptScore W1992588369C526805850 @default.
• W1992588369 hasConceptScore W1992588369C55493867 @default.
• W1992588369 hasConceptScore W1992588369C66090201 @default.
• W1992588369 hasConceptScore W1992588369C71315377 @default.
• W1992588369 hasConceptScore W1992588369C71924100 @default.
• W1992588369 hasConceptScore W1992588369C77231918 @default.
• W1992588369 hasConceptScore W1992588369C86803240 @default.
• W1992588369 hasIssue "1" @default.
• W1992588369 hasLocation W19925883691 @default.
• W1992588369 hasLocation W19925883692 @default.
• W1992588369 hasOpenAccess W1992588369 @default.

• next