FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992592537> ?p ?o ?g. }

• W1992592537 endingPage "85" @default.
• W1992592537 startingPage "79" @default.
• W1992592537 abstract "We have demonstrated previously that dichloroacetate can attenuate skeletal muscle fatigue by up to 35% in a canine model of peripheral ischemia (Timmons, J.A., S.M. Poucher, D. Constantin-Teodosiu, V. Worrall, I.A. Macdonald, and P.L. Greenhaff. 1996. J. Clin. Invest. 97:879-883). This was thought to be a consequence of dichloroacetate increasing acetyl group availability early during contraction. In this study we characterized the metabolic effects of dichloroacetate in a human model of peripheral muscle ischemia. On two separate occasions (control-saline or dichloroacetate infusion), nine subjects performed 8 min of single-leg knee extension exercise at an intensity aimed at achieving volitional exhaustion in approximately 8 min. During exercise each subject's lower limbs were exposed to 50 mmHg of positive pressure, which reduces blood flow by approximately 20%. Dichloroacetate increased resting muscle pyruvate dehydrogenase complex activation status by threefold and elevated acetylcarnitine concentration by fivefold. After 3 min of exercise, phosphocreatine degradation and lactate accumulation were both reduced by approximately 50% after dichloroacetate pretreatment, when compared with control conditions. However, after 8 min of exercise no differences existed between treatments. Therefore, it would appear that dichloroacetate can delay the accumulation of metabolites which lead to the development of skeletal muscle fatigue during ischemia but does not alter the metabolic profile when a maximal effort is approached." @default.
• W1992592537 created "2016-06-24" @default.
• W1992592537 creator A5004761186 @default.
• W1992592537 creator A5005187034 @default.
• W1992592537 creator A5014627032 @default.
• W1992592537 creator A5015042508 @default.
• W1992592537 creator A5023296915 @default.
• W1992592537 creator A5024203094 @default.
• W1992592537 creator A5024467832 @default.
• W1992592537 creator A5060059421 @default.
• W1992592537 creator A5079744734 @default.
• W1992592537 creator A5085953050 @default.
• W1992592537 date "1998-01-01" @default.
• W1992592537 modified "2023-10-14" @default.
• W1992592537 title "Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise." @default.
• W1992592537 cites W1542788366 @default.
• W1992592537 cites W1905278957 @default.
• W1992592537 cites W1955672048 @default.
• W1992592537 cites W1984302000 @default.
• W1992592537 cites W1994148625 @default.
• W1992592537 cites W1994457597 @default.
• W1992592537 cites W1996717739 @default.
• W1992592537 cites W1997052254 @default.
• W1992592537 cites W2002114838 @default.
• W1992592537 cites W2014739390 @default.
• W1992592537 cites W2017987692 @default.
• W1992592537 cites W2024661894 @default.
• W1992592537 cites W2038470332 @default.
• W1992592537 cites W2056982091 @default.
• W1992592537 cites W2063214510 @default.
• W1992592537 cites W2065658266 @default.
• W1992592537 cites W2066042684 @default.
• W1992592537 cites W2071101850 @default.
• W1992592537 cites W2072723731 @default.
• W1992592537 cites W2085294263 @default.
• W1992592537 cites W2091024743 @default.
• W1992592537 cites W2093990877 @default.
• W1992592537 cites W2114512692 @default.
• W1992592537 cites W2123426860 @default.
• W1992592537 cites W2156601886 @default.
• W1992592537 cites W2158923004 @default.
• W1992592537 cites W2163076148 @default.
• W1992592537 cites W2169915927 @default.
• W1992592537 cites W2173556929 @default.
• W1992592537 cites W2188563884 @default.
• W1992592537 cites W2287535885 @default.
• W1992592537 cites W2298674995 @default.
• W1992592537 cites W2304044976 @default.
• W1992592537 cites W2339711330 @default.
• W1992592537 cites W2410463692 @default.
• W1992592537 cites W2419921303 @default.
• W1992592537 cites W4248786683 @default.
• W1992592537 cites W641720172 @default.
• W1992592537 doi "https://doi.org/10.1172/jci1146" @default.
• W1992592537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/508543" @default.
• W1992592537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9421469" @default.
• W1992592537 hasPublicationYear "1998" @default.
• W1992592537 type Work @default.
• W1992592537 sameAs 1992592537 @default.
• W1992592537 citedByCount "80" @default.
• W1992592537 countsByYear W19925925372012 @default.
• W1992592537 countsByYear W19925925372013 @default.
• W1992592537 countsByYear W19925925372014 @default.
• W1992592537 countsByYear W19925925372015 @default.
• W1992592537 countsByYear W19925925372016 @default.
• W1992592537 countsByYear W19925925372017 @default.
• W1992592537 countsByYear W19925925372018 @default.
• W1992592537 countsByYear W19925925372019 @default.
• W1992592537 countsByYear W19925925372020 @default.
• W1992592537 countsByYear W19925925372023 @default.
• W1992592537 crossrefType "journal-article" @default.
• W1992592537 hasAuthorship W1992592537A5004761186 @default.
• W1992592537 hasAuthorship W1992592537A5005187034 @default.
• W1992592537 hasAuthorship W1992592537A5014627032 @default.
• W1992592537 hasAuthorship W1992592537A5015042508 @default.
• W1992592537 hasAuthorship W1992592537A5023296915 @default.
• W1992592537 hasAuthorship W1992592537A5024203094 @default.
• W1992592537 hasAuthorship W1992592537A5024467832 @default.
• W1992592537 hasAuthorship W1992592537A5060059421 @default.
• W1992592537 hasAuthorship W1992592537A5079744734 @default.
• W1992592537 hasAuthorship W1992592537A5085953050 @default.
• W1992592537 hasBestOaLocation W19925925371 @default.
• W1992592537 hasConcept C126322002 @default.
• W1992592537 hasConcept C134018914 @default.
• W1992592537 hasConcept C181199279 @default.
• W1992592537 hasConcept C181588539 @default.
• W1992592537 hasConcept C185592680 @default.
• W1992592537 hasConcept C20251656 @default.
• W1992592537 hasConcept C2776050358 @default.
• W1992592537 hasConcept C2778626300 @default.
• W1992592537 hasConcept C2779959927 @default.
• W1992592537 hasConcept C2986317502 @default.
• W1992592537 hasConcept C541997718 @default.
• W1992592537 hasConcept C55493867 @default.
• W1992592537 hasConcept C62231903 @default.
• W1992592537 hasConcept C71924100 @default.
• W1992592537 hasConcept C88099638 @default.
• W1992592537 hasConceptScore W1992592537C126322002 @default.

• next