FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992617650> ?p ?o ?g. }

• W1992617650 abstract "It is increasingly recognised that mitochondria are potential targets to pharmacological and toxicological actions of membrane-active agents, including some 1,4-dihydropyridines derivatives (DHPs). The 5-acetyl(carbamoyl)-6-methylsulfanyl-1,4-dihydropyridine-5-carbonitriles (OSI-1146, OSI-3701, OSI-3761, and OSI-9642) is a new group of DHPs with minor differences on the molecular structure. It has also been shown that OSI-1146 displays cardiovascular, antioxidant, and antiradical activities, whereas OSI-3701 and OSI-3761 display hepatoprotective activity. Due to their protective properties, this group of DHPs may be potentially useful for the treatment of several pathological processes, including those associated with oxidative stress. However, the cellular targets for their pharmacological actions have not been investigated. The presented study, using isolated rat liver mitochondria was designed to investigate if mitochondria are a cellular target for the pharmacological and/or toxicological actions of these new group of DHPs. We studied the direct influence of these DHPs on rat liver mitochondrial function [bioenergetics, membrane permeability transition (MPT), and oxidative stress]. It was shown that OSI-1146, OSI-3761, and OSI-9642, in the concentration range of up to 200 microM, interfered with mitochondrial bioenergetics by affecting complexes I and II of the mitochondrial respiratory chain, the ATPase activity, and mitochondrial inner membrane permeability to protons. However, the effects of OSI-1146 were higher than those of OSI-3761 and OSI-9642. The remaining compound, OSI-3701, had no effect on the bioenergetic parameters tested. All the compounds increased the susceptibility of mitochondria to MPT, but, OSI-3701, not affecting the bioenergetic parameters, was the most potent. Moreover, all the compounds protected mitochondria against lipid peroxidation induced by the oxidant pair ADP/Fe(2+), but OSI-1146 was also the most potent. In conclusion, our results indicate that mitochondria are the potential intracellular targets for both protective and toxicological actions of the DHP compounds studied, suggesting that the potential use of these compounds as therapeutic agents should carefully consider their toxic effects to mitochondria." @default.
• W1992617650 created "2016-06-24" @default.
• W1992617650 creator A5026086117 @default.
• W1992617650 creator A5034147713 @default.
• W1992617650 creator A5041425326 @default.
• W1992617650 creator A5059689215 @default.
• W1992617650 creator A5067035581 @default.
• W1992617650 creator A5067565958 @default.
• W1992617650 creator A5070918468 @default.
• W1992617650 date "2009-10-01" @default.
• W1992617650 modified "2023-09-22" @default.
• W1992617650 title "Effects of 5-acetyl(carbamoyl)-6-methylsulfanyl-1,4-dihydropyridine-5-carbonitriles on rat liver mitochondrial function" @default.
• W1992617650 cites W1492823505 @default.
• W1992617650 cites W1506043065 @default.
• W1992617650 cites W1590457525 @default.
• W1992617650 cites W175613554 @default.
• W1992617650 cites W1968926794 @default.
• W1992617650 cites W1975796346 @default.
• W1992617650 cites W1985979907 @default.
• W1992617650 cites W2002802640 @default.
• W1992617650 cites W2008757391 @default.
• W1992617650 cites W2019044547 @default.
• W1992617650 cites W2020653435 @default.
• W1992617650 cites W2022377698 @default.
• W1992617650 cites W2037057064 @default.
• W1992617650 cites W2052406949 @default.
• W1992617650 cites W2067780422 @default.
• W1992617650 cites W2077316760 @default.
• W1992617650 cites W2082052172 @default.
• W1992617650 cites W2083079034 @default.
• W1992617650 cites W2086498287 @default.
• W1992617650 cites W2112093095 @default.
• W1992617650 cites W2171154502 @default.
• W1992617650 cites W2332495141 @default.
• W1992617650 cites W2342695120 @default.
• W1992617650 cites W2460963447 @default.
• W1992617650 cites W2949830540 @default.
• W1992617650 cites W2269655640 @default.
• W1992617650 cites W2401406052 @default.
• W1992617650 doi "https://doi.org/10.1016/j.tiv.2009.07.002" @default.
• W1992617650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19596436" @default.
• W1992617650 hasPublicationYear "2009" @default.
• W1992617650 type Work @default.
• W1992617650 sameAs 1992617650 @default.
• W1992617650 citedByCount "6" @default.
• W1992617650 countsByYear W19926176502012 @default.
• W1992617650 countsByYear W19926176502013 @default.
• W1992617650 countsByYear W19926176502014 @default.
• W1992617650 countsByYear W19926176502016 @default.
• W1992617650 crossrefType "journal-article" @default.
• W1992617650 hasAuthorship W1992617650A5026086117 @default.
• W1992617650 hasAuthorship W1992617650A5034147713 @default.
• W1992617650 hasAuthorship W1992617650A5041425326 @default.
• W1992617650 hasAuthorship W1992617650A5059689215 @default.
• W1992617650 hasAuthorship W1992617650A5067035581 @default.
• W1992617650 hasAuthorship W1992617650A5067565958 @default.
• W1992617650 hasAuthorship W1992617650A5070918468 @default.
• W1992617650 hasConcept C100206155 @default.
• W1992617650 hasConcept C178790620 @default.
• W1992617650 hasConcept C185592680 @default.
• W1992617650 hasConcept C203014093 @default.
• W1992617650 hasConcept C2776151105 @default.
• W1992617650 hasConcept C2778048844 @default.
• W1992617650 hasConcept C2778371730 @default.
• W1992617650 hasConcept C2780866276 @default.
• W1992617650 hasConcept C2781212610 @default.
• W1992617650 hasConcept C28859421 @default.
• W1992617650 hasConcept C519063684 @default.
• W1992617650 hasConcept C55493867 @default.
• W1992617650 hasConcept C86803240 @default.
• W1992617650 hasConcept C98274493 @default.
• W1992617650 hasConceptScore W1992617650C100206155 @default.
• W1992617650 hasConceptScore W1992617650C178790620 @default.
• W1992617650 hasConceptScore W1992617650C185592680 @default.
• W1992617650 hasConceptScore W1992617650C203014093 @default.
• W1992617650 hasConceptScore W1992617650C2776151105 @default.
• W1992617650 hasConceptScore W1992617650C2778048844 @default.
• W1992617650 hasConceptScore W1992617650C2778371730 @default.
• W1992617650 hasConceptScore W1992617650C2780866276 @default.
• W1992617650 hasConceptScore W1992617650C2781212610 @default.
• W1992617650 hasConceptScore W1992617650C28859421 @default.
• W1992617650 hasConceptScore W1992617650C519063684 @default.
• W1992617650 hasConceptScore W1992617650C55493867 @default.
• W1992617650 hasConceptScore W1992617650C86803240 @default.
• W1992617650 hasConceptScore W1992617650C98274493 @default.
• W1992617650 hasLocation W19926176501 @default.
• W1992617650 hasLocation W19926176502 @default.
• W1992617650 hasOpenAccess W1992617650 @default.
• W1992617650 hasPrimaryLocation W19926176501 @default.
• W1992617650 hasRelatedWork W1503432244 @default.
• W1992617650 hasRelatedWork W1896019570 @default.
• W1992617650 hasRelatedWork W1969965322 @default.
• W1992617650 hasRelatedWork W1979162928 @default.
• W1992617650 hasRelatedWork W1982009338 @default.
• W1992617650 hasRelatedWork W2023295106 @default.
• W1992617650 hasRelatedWork W2023956494 @default.
• W1992617650 hasRelatedWork W2045860863 @default.
• W1992617650 hasRelatedWork W2054553970 @default.
• W1992617650 hasRelatedWork W2065359879 @default.
• W1992617650 hasRelatedWork W2077059499 @default.

• next