FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992625706> ?p ?o ?g. }

• W1992625706 endingPage "605" @default.
• W1992625706 startingPage "594" @default.
• W1992625706 abstract "To compare pain relief among various dose-fractionation schedules of localized radiotherapy (RT) in the treatment of painful bone metastases.A systematic search for randomized trials of localized RT on bone metastases using different dose fractionations was performed using Medline (1966 to February 2001) and other sources. The primary outcomes of interest were complete and overall pain relief. The studies were divided into three groups: comparisons of doses given as a single fraction, single vs. multiple fractions, and comparisons of doses given as multiple fractions. The complete and overall pain responses for studies comparing single vs. multiple fractions were pooled. Exploratory analyses of the dose-response relationship, using the biologic effective dose (alpha/beta = 10), were performed using results from all three groups of trials.Two trials comparing single vs. single, eight trials comparing single vs. multiple, and six trials comparing multiple vs. multiple fractions were included. The complete and overall response rates from studies comparing single-fraction RT (median 8 Gy, range 8-10 Gy) against multifraction RT (median 20 Gy in 5 fractions, range 20 Gy in 5 fractions to 30 Gy in 10 fractions) were homogeneous and allowed pooling of data. Of 3260 randomized patients in seven studies, 539 (33.4%) of 1613 and 523 (32.3%) of 1618 patients achieved a complete response after single and multifraction RT, respectively, giving a risk ratio of 1.03 (95% confidence interval 0.94-1.14; p = 0.5). The overall response rate was in favor of single-fraction RT (1011 [62.1%] of 1629) compared with multifraction (958 [58.7%] of 1631; risk ratio 1.05, 95% confidence interval 1.00-1.11, p = 0.04), reaching statistical significance. However, when the analysis was restricted to evaluated patients alone, the overall response rates were similar for single fraction and multifraction RT, at 1011 (72.7%) of 1391 and 958 (72.5%) of 1321, respectively (risk ratio 1.00; p = 0.9). Exploratory analyses by biologic effective dose did not reveal any dose-response relationship among the fractionation schedules used (single 8 Gy to 40 Gy in 15 fractions). Of the other results and observations reported in the trials, only the re-irradiation rates were consistently different between the treatment arms (more frequent re-irradiation in lower dose arms among trials reporting re-irradiation rates).Meta-analysis of reported randomized trials shows no significant difference in complete and overall pain relief between single and multifraction palliative RT for bone metastases. No dose-response relationship could be detected by including data from the multifraction vs. multifraction trials. Additional data are needed to evaluate the role of re-irradiation and the impact of RT on other treatment end points such as quality of life." @default.
• W1992625706 created "2016-06-24" @default.
• W1992625706 creator A5002216968 @default.
• W1992625706 creator A5011668738 @default.
• W1992625706 creator A5027918729 @default.
• W1992625706 creator A5040285878 @default.
• W1992625706 creator A5074766009 @default.
• W1992625706 date "2003-03-01" @default.
• W1992625706 modified "2023-10-16" @default.
• W1992625706 title "Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases" @default.
• W1992625706 cites W1982136835 @default.
• W1992625706 cites W1984170181 @default.
• W1992625706 cites W1986215651 @default.
• W1992625706 cites W1989098069 @default.
• W1992625706 cites W1990718568 @default.
• W1992625706 cites W1999978652 @default.
• W1992625706 cites W2000016107 @default.
• W1992625706 cites W2009700462 @default.
• W1992625706 cites W2015669671 @default.
• W1992625706 cites W2023141374 @default.
• W1992625706 cites W2031145335 @default.
• W1992625706 cites W2036541203 @default.
• W1992625706 cites W2041568526 @default.
• W1992625706 cites W2047842438 @default.
• W1992625706 cites W2065272001 @default.
• W1992625706 cites W2066553392 @default.
• W1992625706 cites W2078574113 @default.
• W1992625706 cites W2080661941 @default.
• W1992625706 cites W2089009335 @default.
• W1992625706 cites W2099046402 @default.
• W1992625706 cites W2108145085 @default.
• W1992625706 cites W2118459509 @default.
• W1992625706 cites W2122244986 @default.
• W1992625706 cites W2124512147 @default.
• W1992625706 cites W2126697292 @default.
• W1992625706 cites W2136392842 @default.
• W1992625706 cites W2154346936 @default.
• W1992625706 cites W2471904951 @default.
• W1992625706 doi "https://doi.org/10.1016/s0360-3016(02)04147-0" @default.
• W1992625706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12573746" @default.
• W1992625706 hasPublicationYear "2003" @default.
• W1992625706 type Work @default.
• W1992625706 sameAs 1992625706 @default.
• W1992625706 citedByCount "523" @default.
• W1992625706 countsByYear W19926257062012 @default.
• W1992625706 countsByYear W19926257062013 @default.
• W1992625706 countsByYear W19926257062014 @default.
• W1992625706 countsByYear W19926257062015 @default.
• W1992625706 countsByYear W19926257062016 @default.
• W1992625706 countsByYear W19926257062017 @default.
• W1992625706 countsByYear W19926257062018 @default.
• W1992625706 countsByYear W19926257062019 @default.
• W1992625706 countsByYear W19926257062020 @default.
• W1992625706 countsByYear W19926257062021 @default.
• W1992625706 countsByYear W19926257062022 @default.
• W1992625706 countsByYear W19926257062023 @default.
• W1992625706 crossrefType "journal-article" @default.
• W1992625706 hasAuthorship W1992625706A5002216968 @default.
• W1992625706 hasAuthorship W1992625706A5011668738 @default.
• W1992625706 hasAuthorship W1992625706A5027918729 @default.
• W1992625706 hasAuthorship W1992625706A5040285878 @default.
• W1992625706 hasAuthorship W1992625706A5074766009 @default.
• W1992625706 hasConcept C126322002 @default.
• W1992625706 hasConcept C141071460 @default.
• W1992625706 hasConcept C155806632 @default.
• W1992625706 hasConcept C168563851 @default.
• W1992625706 hasConcept C2989005 @default.
• W1992625706 hasConcept C44249647 @default.
• W1992625706 hasConcept C509974204 @default.
• W1992625706 hasConcept C535046627 @default.
• W1992625706 hasConcept C71924100 @default.
• W1992625706 hasConceptScore W1992625706C126322002 @default.
• W1992625706 hasConceptScore W1992625706C141071460 @default.
• W1992625706 hasConceptScore W1992625706C155806632 @default.
• W1992625706 hasConceptScore W1992625706C168563851 @default.
• W1992625706 hasConceptScore W1992625706C2989005 @default.
• W1992625706 hasConceptScore W1992625706C44249647 @default.
• W1992625706 hasConceptScore W1992625706C509974204 @default.
• W1992625706 hasConceptScore W1992625706C535046627 @default.
• W1992625706 hasConceptScore W1992625706C71924100 @default.
• W1992625706 hasIssue "3" @default.
• W1992625706 hasLocation W19926257061 @default.
• W1992625706 hasLocation W19926257062 @default.
• W1992625706 hasOpenAccess W1992625706 @default.
• W1992625706 hasPrimaryLocation W19926257061 @default.
• W1992625706 hasRelatedWork W1919433043 @default.
• W1992625706 hasRelatedWork W2002120878 @default.
• W1992625706 hasRelatedWork W2024519167 @default.
• W1992625706 hasRelatedWork W2047967234 @default.
• W1992625706 hasRelatedWork W2069559326 @default.
• W1992625706 hasRelatedWork W2113848764 @default.
• W1992625706 hasRelatedWork W2118496982 @default.
• W1992625706 hasRelatedWork W2255894970 @default.
• W1992625706 hasRelatedWork W2439875401 @default.
• W1992625706 hasRelatedWork W4307146680 @default.
• W1992625706 hasVolume "55" @default.
• W1992625706 isParatext "false" @default.
• W1992625706 isRetracted "false" @default.

• next