FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992648442> ?p ?o ?g. }

• W1992648442 endingPage "607" @default.
• W1992648442 startingPage "593" @default.
• W1992648442 abstract "Exposure of biological membranes to reactive oxygen species creates a complex mixture of distinct oxidized phospholipid (OxPL) species, which contribute to the development of chronic inflammatory diseases and metabolic disorders. While the ability of OxPL to modulate biological processes is increasingly recognized, the nature of the biologically active OxPL species and the molecular mechanisms underlying their signaling remain largely unknown. We have employed a combination of mass spectrometry, synthetic chemistry, and immunobiology approaches to characterize the OxPL generated from the abundant phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC) and investigated their bioactivities and signaling pathways in vitro and in vivo. Our study defines epoxycyclopentenones as potent anti-inflammatory lipid mediators that mimic the signaling of endogenous, pro-resolving prostanoids by activating the transcription factor nuclear factor E2-related factor 2 (Nrf2). Using a library of OxPL variants, we identified a synthetic OxPL derivative, which alleviated endotoxin-induced lung injury and inhibited development of pro-inflammatory T helper (Th) 1 cells. These findings provide a molecular basis for the negative regulation of inflammation by lipid peroxidation products and propose a novel class of highly bioactive compounds for the treatment of inflammatory diseases." @default.
• W1992648442 created "2016-06-24" @default.
• W1992648442 creator A5006544772 @default.
• W1992648442 creator A5006868869 @default.
• W1992648442 creator A5018100825 @default.
• W1992648442 creator A5048086369 @default.
• W1992648442 creator A5049997686 @default.
• W1992648442 creator A5066333579 @default.
• W1992648442 creator A5076529012 @default.
• W1992648442 creator A5087304114 @default.
• W1992648442 date "2015-03-13" @default.
• W1992648442 modified "2023-10-16" @default.
• W1992648442 title "Phospholipid oxidation generates potent anti‐inflammatory lipid mediators that mimic structurally related pro‐resolving eicosanoids by activating Nrf2" @default.
• W1992648442 cites W1507384265 @default.
• W1992648442 cites W1989984065 @default.
• W1992648442 cites W1991631628 @default.
• W1992648442 cites W2001003686 @default.
• W1992648442 cites W2008311655 @default.
• W1992648442 cites W2010008322 @default.
• W1992648442 cites W2045772297 @default.
• W1992648442 cites W2049487043 @default.
• W1992648442 cites W2053561492 @default.
• W1992648442 cites W2055047003 @default.
• W1992648442 cites W2062097745 @default.
• W1992648442 cites W2063116304 @default.
• W1992648442 cites W2064112171 @default.
• W1992648442 cites W2065947716 @default.
• W1992648442 cites W2096261918 @default.
• W1992648442 cites W2104174436 @default.
• W1992648442 cites W2109961974 @default.
• W1992648442 cites W2112799653 @default.
• W1992648442 cites W2113971187 @default.
• W1992648442 cites W2114675972 @default.
• W1992648442 cites W2120290311 @default.
• W1992648442 cites W2123918140 @default.
• W1992648442 cites W2126408606 @default.
• W1992648442 cites W2128838307 @default.
• W1992648442 cites W2135289253 @default.
• W1992648442 cites W2137511741 @default.
• W1992648442 cites W2139817528 @default.
• W1992648442 cites W2143481724 @default.
• W1992648442 cites W2143506134 @default.
• W1992648442 cites W2143951282 @default.
• W1992648442 cites W2146576926 @default.
• W1992648442 cites W2148989921 @default.
• W1992648442 cites W2156613610 @default.
• W1992648442 cites W2170983723 @default.
• W1992648442 cites W3022864527 @default.
• W1992648442 cites W4248752794 @default.
• W1992648442 doi "https://doi.org/10.15252/emmm.201404702" @default.
• W1992648442 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4492819" @default.
• W1992648442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25770125" @default.
• W1992648442 hasPublicationYear "2015" @default.
• W1992648442 type Work @default.
• W1992648442 sameAs 1992648442 @default.
• W1992648442 citedByCount "76" @default.
• W1992648442 countsByYear W19926484422015 @default.
• W1992648442 countsByYear W19926484422016 @default.
• W1992648442 countsByYear W19926484422017 @default.
• W1992648442 countsByYear W19926484422018 @default.
• W1992648442 countsByYear W19926484422019 @default.
• W1992648442 countsByYear W19926484422020 @default.
• W1992648442 countsByYear W19926484422021 @default.
• W1992648442 countsByYear W19926484422022 @default.
• W1992648442 countsByYear W19926484422023 @default.
• W1992648442 crossrefType "journal-article" @default.
• W1992648442 hasAuthorship W1992648442A5006544772 @default.
• W1992648442 hasAuthorship W1992648442A5006868869 @default.
• W1992648442 hasAuthorship W1992648442A5018100825 @default.
• W1992648442 hasAuthorship W1992648442A5048086369 @default.
• W1992648442 hasAuthorship W1992648442A5049997686 @default.
• W1992648442 hasAuthorship W1992648442A5066333579 @default.
• W1992648442 hasAuthorship W1992648442A5076529012 @default.
• W1992648442 hasAuthorship W1992648442A5087304114 @default.
• W1992648442 hasBestOaLocation W19926484422 @default.
• W1992648442 hasConcept C104317684 @default.
• W1992648442 hasConcept C150903083 @default.
• W1992648442 hasConcept C16613235 @default.
• W1992648442 hasConcept C170493617 @default.
• W1992648442 hasConcept C180899940 @default.
• W1992648442 hasConcept C185592680 @default.
• W1992648442 hasConcept C202751555 @default.
• W1992648442 hasConcept C203014093 @default.
• W1992648442 hasConcept C207001950 @default.
• W1992648442 hasConcept C2776914184 @default.
• W1992648442 hasConcept C2778754761 @default.
• W1992648442 hasConcept C2778918659 @default.
• W1992648442 hasConcept C41625074 @default.
• W1992648442 hasConcept C48349386 @default.
• W1992648442 hasConcept C55493867 @default.
• W1992648442 hasConcept C62478195 @default.
• W1992648442 hasConcept C86339819 @default.
• W1992648442 hasConcept C86803240 @default.
• W1992648442 hasConcept C95444343 @default.
• W1992648442 hasConceptScore W1992648442C104317684 @default.
• W1992648442 hasConceptScore W1992648442C150903083 @default.
• W1992648442 hasConceptScore W1992648442C16613235 @default.
• W1992648442 hasConceptScore W1992648442C170493617 @default.

• next