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- W1992648645 abstract "LEFLUNOMIDE: A NOVEL THERAPEUTIC AGENT FOR GANCICLOVIRRESISTANT CYTOMEGALOVIRUS IN KIDNEY TRANSPLANT RECIPIENTS Eram Shahira, Beje Thomas, Manish Talwar, Maria Salazar, Takamitsu Saigusa, Sarat Kuppachi, M. Francesca Egidi Medical University Of South Carolina, Charleston, South Carolina. Cytomegalovirus (CMV) is the most common viral infec on in solid organ transplant; 20%-60% of transplanted pa ents develop symptoma c CMV infec on despite specific prophylaxis. First line treatment for CMV reac va on and disease presently includes ganciclovir or valganciclovir. Cidofovir and foscarnet because of their nephrotoxicity should be considered in case of failure of the tradi onal treatment. Leflunomide is a drug approved for the treatment of rheumatoid arthri s that has been shown to have an CMV ac vity without nephrotoxicity. We report our experience with four pa ents who developed CMV reac va on and subsequent disease and failed treatment with ganciclovir and immunosuppression (IS) reduc on. Leflunomide (LF) was ini ated at the dose of 40 mg PO/daily. All of the pa ents received cadaveric renal transplants, had T-cell deple ng agent induc on (Thymoglobulin) and maintenance IS consis ng in prednisone, cellcept and tacrolimus. The viremia was monitored and detected with rou ne CMV/PCR screening. The pa ents’ characteris cs and results are shown in the table. Age at the Transplant Race/Gender CMV status (IgG) D/R Diagnosis from transplant (Months) Time to response to Leflunomide (Weeks) Pt.LB 49 C/F +/6 4 Pt.CB 38 AA/M +/2 4 Pt.CH 41 C/M +/6 5 Pt .SA 51 C/M +/+ 24 3 In conclusion our preliminary results show that LF offers an alterna ve to tradi onal an -CMV therapies for the transplant recipient with an viral resistance." @default.
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- W1992648645 date "2011-04-01" @default.
- W1992648645 modified "2023-09-25" @default.
- W1992648645 title "281 Leflunomide: A Novel Therapeutic Agent for Ganciclovir-Resistant Cytomegalovirus in Kidney Transplant Recipients" @default.
- W1992648645 doi "https://doi.org/10.1053/j.ajkd.2011.02.284" @default.
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