FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992651810> ?p ?o ?g. }

• W1992651810 endingPage "69" @default.
• W1992651810 startingPage "51" @default.
• W1992651810 abstract "The breaking of immune tolerance against angiogenesis-associated molecules should be a useful approach for cancer therapy by active immunity. We used chicken integrin β3 as a model antigen to explore the feasibility of immunogene therapy of the tumors with a vaccine based on a single xenogeneic homologous gene, targeting the molecules associated with angiogenesis. To test this concept we constructed a plasmid DNA encoding the ligand-binding domain of chicken integrin β3 (P-BD-C) and control vectors. We found that immunogene therapy of tumors with a vaccine based on the ligand-binding domain of chicken integrin β3 (P-BD-C) was effective in both protective and therapeutic anti-tumor immunity in several tumor models in mice. Autoantibodies against integrin β3 in sera of mice immunized with the ligand-binding domain of chicken integrin β3 could be found by Western blot analysis and ELISA assay. The purified immunoglobulins were effective in the inhibition of endothelial cell proliferation in vitro, and in anti-tumor activity as well as in the inhibition of angiogenesis by adoptive transfer in vivo. The anti-tumor activity and the production of integrin β3-specific autoantibodies (manifested by significantly elevated Ig G1 and Ig G2b) could be abrogated by the depletion of CD4+ T lymphocytes. These observations may provide a vaccine strategy for cancer therapy through the induction of the autoimmunity against the molecules associated with tumor growth in a cross-reaction with a single xenogeneic homologous gene and may be of importance in the further exploration of the applications of other xenogeneic homologous genes identified in human and other animal genome sequence projects in cancer therapy." @default.
• W1992651810 created "2016-06-24" @default.
• W1992651810 creator A5001504110 @default.
• W1992651810 creator A5006117659 @default.
• W1992651810 creator A5012362972 @default.
• W1992651810 creator A5017501850 @default.
• W1992651810 creator A5032988856 @default.
• W1992651810 creator A5044693503 @default.
• W1992651810 creator A5048200579 @default.
• W1992651810 creator A5054610205 @default.
• W1992651810 creator A5058006003 @default.
• W1992651810 creator A5061188546 @default.
• W1992651810 creator A5064235409 @default.
• W1992651810 creator A5066446295 @default.
• W1992651810 creator A5070368039 @default.
• W1992651810 creator A5071513700 @default.
• W1992651810 creator A5072179350 @default.
• W1992651810 creator A5082744746 @default.
• W1992651810 creator A5083106186 @default.
• W1992651810 creator A5086592087 @default.
• W1992651810 creator A5086792341 @default.
• W1992651810 creator A5087859400 @default.
• W1992651810 creator A5090596512 @default.
• W1992651810 creator A5091198078 @default.
• W1992651810 date "2002-01-01" @default.
• W1992651810 modified "2023-10-17" @default.
• W1992651810 title "IMMUNOGENE THERAPY OF TUMORS WITH A VACCINE BASED ON THE LIGAND-BINDING DOMAIN OF CHICKEN HOMOLOGOUS INTEGRIN<i>β</i>₃" @default.
• W1992651810 cites W1543245226 @default.
• W1992651810 cites W1545819550 @default.
• W1992651810 cites W1554296669 @default.
• W1992651810 cites W1656991593 @default.
• W1992651810 cites W1679229092 @default.
• W1992651810 cites W1762724222 @default.
• W1992651810 cites W1938388466 @default.
• W1992651810 cites W1971753852 @default.
• W1992651810 cites W1972922050 @default.
• W1992651810 cites W1974620735 @default.
• W1992651810 cites W1981486175 @default.
• W1992651810 cites W1983285913 @default.
• W1992651810 cites W2001753204 @default.
• W1992651810 cites W2008181555 @default.
• W1992651810 cites W2021840830 @default.
• W1992651810 cites W2029231027 @default.
• W1992651810 cites W2029264605 @default.
• W1992651810 cites W2029773366 @default.
• W1992651810 cites W2031630601 @default.
• W1992651810 cites W2035489557 @default.
• W1992651810 cites W2035572849 @default.
• W1992651810 cites W2052877553 @default.
• W1992651810 cites W2053508680 @default.
• W1992651810 cites W2064070322 @default.
• W1992651810 cites W2073308580 @default.
• W1992651810 cites W2073965889 @default.
• W1992651810 cites W2093830420 @default.
• W1992651810 cites W2096868396 @default.
• W1992651810 cites W2100363932 @default.
• W1992651810 cites W2113267611 @default.
• W1992651810 cites W2113324173 @default.
• W1992651810 cites W2116293732 @default.
• W1992651810 cites W2131798870 @default.
• W1992651810 cites W2149003800 @default.
• W1992651810 cites W2152237445 @default.
• W1992651810 cites W2158743409 @default.
• W1992651810 cites W2158965678 @default.
• W1992651810 cites W2258274645 @default.
• W1992651810 cites W2319962899 @default.
• W1992651810 cites W4235786354 @default.
• W1992651810 doi "https://doi.org/10.1081/imm-120003221" @default.
• W1992651810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11990463" @default.
• W1992651810 hasPublicationYear "2002" @default.
• W1992651810 type Work @default.
• W1992651810 sameAs 1992651810 @default.
• W1992651810 citedByCount "22" @default.
• W1992651810 countsByYear W19926518102012 @default.
• W1992651810 countsByYear W19926518102013 @default.
• W1992651810 countsByYear W19926518102014 @default.
• W1992651810 countsByYear W19926518102015 @default.
• W1992651810 countsByYear W19926518102021 @default.
• W1992651810 crossrefType "journal-article" @default.
• W1992651810 hasAuthorship W1992651810A5001504110 @default.
• W1992651810 hasAuthorship W1992651810A5006117659 @default.
• W1992651810 hasAuthorship W1992651810A5012362972 @default.
• W1992651810 hasAuthorship W1992651810A5017501850 @default.
• W1992651810 hasAuthorship W1992651810A5032988856 @default.
• W1992651810 hasAuthorship W1992651810A5044693503 @default.
• W1992651810 hasAuthorship W1992651810A5048200579 @default.
• W1992651810 hasAuthorship W1992651810A5054610205 @default.
• W1992651810 hasAuthorship W1992651810A5058006003 @default.
• W1992651810 hasAuthorship W1992651810A5061188546 @default.
• W1992651810 hasAuthorship W1992651810A5064235409 @default.
• W1992651810 hasAuthorship W1992651810A5066446295 @default.
• W1992651810 hasAuthorship W1992651810A5070368039 @default.
• W1992651810 hasAuthorship W1992651810A5071513700 @default.
• W1992651810 hasAuthorship W1992651810A5072179350 @default.
• W1992651810 hasAuthorship W1992651810A5082744746 @default.
• W1992651810 hasAuthorship W1992651810A5083106186 @default.
• W1992651810 hasAuthorship W1992651810A5086592087 @default.
• W1992651810 hasAuthorship W1992651810A5086792341 @default.

• next