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• W1992657945 abstract "Loss of N7-methylguanosine (m7G) modification is involved in the recently discovered rapid tRNA degradation pathway. In yeast, this modification is catalyzed by the heterodimeric complex composed of a catalytic subunit Trm8 and a noncatalytic subunit Trm82. We have solved the crystal structure of Trm8 alone and in complex with Trm82. Trm8 undergoes subtle conformational changes upon Trm82 binding which explains the requirement of Trm82 for activity. Cocrystallization with the S-adenosyl-methionine methyl donor defines the putative catalytic site and a guanine binding pocket. Small-angle X-ray scattering in solution of the Trm8-Trm82 heterodimer in complex with tRNA(Phe) has enabled us to propose a low-resolution structure of the ternary complex which defines the tRNA binding mode of Trm8-Trm82 and the structural elements contributing to specificity." @default.
• W1992657945 created "2016-06-24" @default.
• W1992657945 creator A5004357736 @default.
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• W1992657945 creator A5041703234 @default.
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• W1992657945 date "2008-01-01" @default.
• W1992657945 modified "2023-10-17" @default.
• W1992657945 title "Structure of the Yeast tRNA m7G Methylation Complex" @default.
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• W1992657945 doi "https://doi.org/10.1016/j.str.2007.10.025" @default.
• W1992657945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18184583" @default.
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