FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992667514> ?p ?o ?g. }

• W1992667514 abstract "Abstract Background The Orf virus (ORFV), a zoonotic Parapoxvirus, causes pustular skin lesions in small ruminants (goat and sheep). Intriguingly, ORFV can repeatedly infect its host, despite the induction of a specific immunity. These immune modulating and immune evading properties are still unexplained. Results Here, we describe that ORFV infection of permissive cells impairs the intracellular transport of MHC class I molecules (MHC I) as a result of structural disruption and fragmentation of the Golgi apparatus. Depending on the duration of infection, we observed a pronounced co-localization of MHC I and COP-I vesicular structures as well as a reduction of MHC I surface expression of up to 50%. These subversion processes are associated with early ORFV gene expression and are accompanied by disturbed carbohydrate trimming of post-ER MHC I. The MHC I population remaining on the cell surface shows an extended half-life, an effect that might be partially controlled also by late ORFV genes. Conclusions The presented data demonstrate that ORFV down-regulates MHC I surface expression in infected cells by targeting the late vesicular export machinery and the structure and function of the Golgi apparatus, which might aid to escape cellular immune recognition." @default.
• W1992667514 created "2016-06-24" @default.
• W1992667514 creator A5002946069 @default.
• W1992667514 creator A5033477493 @default.
• W1992667514 creator A5041414302 @default.
• W1992667514 creator A5043070294 @default.
• W1992667514 date "2012-07-18" @default.
• W1992667514 modified "2023-10-02" @default.
• W1992667514 title "Orf virus interferes with MHC class I surface expression by targeting vesicular transport and Golgi" @default.
• W1992667514 cites W123325772 @default.
• W1992667514 cites W1491787713 @default.
• W1992667514 cites W1495638035 @default.
• W1992667514 cites W1543119869 @default.
• W1992667514 cites W1573670866 @default.
• W1992667514 cites W1591933828 @default.
• W1992667514 cites W1717764253 @default.
• W1992667514 cites W1907618785 @default.
• W1992667514 cites W1977920719 @default.
• W1992667514 cites W1985475828 @default.
• W1992667514 cites W2001871013 @default.
• W1992667514 cites W2006233454 @default.
• W1992667514 cites W2009176000 @default.
• W1992667514 cites W2023651588 @default.
• W1992667514 cites W2037410317 @default.
• W1992667514 cites W2038363929 @default.
• W1992667514 cites W2040191405 @default.
• W1992667514 cites W2049379679 @default.
• W1992667514 cites W2074049033 @default.
• W1992667514 cites W2077301497 @default.
• W1992667514 cites W2078263624 @default.
• W1992667514 cites W2079407464 @default.
• W1992667514 cites W2081767364 @default.
• W1992667514 cites W2086008461 @default.
• W1992667514 cites W2090931101 @default.
• W1992667514 cites W2091792931 @default.
• W1992667514 cites W2100178766 @default.
• W1992667514 cites W2101328506 @default.
• W1992667514 cites W2109851366 @default.
• W1992667514 cites W2115668602 @default.
• W1992667514 cites W2118286268 @default.
• W1992667514 cites W2119047742 @default.
• W1992667514 cites W2120580958 @default.
• W1992667514 cites W2129419245 @default.
• W1992667514 cites W2132197730 @default.
• W1992667514 cites W2132913569 @default.
• W1992667514 cites W2135910305 @default.
• W1992667514 cites W2138004014 @default.
• W1992667514 cites W2138195465 @default.
• W1992667514 cites W2168375114 @default.
• W1992667514 doi "https://doi.org/10.1186/1746-6148-8-114" @default.
• W1992667514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3439706" @default.
• W1992667514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22809544" @default.
• W1992667514 hasPublicationYear "2012" @default.
• W1992667514 type Work @default.
• W1992667514 sameAs 1992667514 @default.
• W1992667514 citedByCount "15" @default.
• W1992667514 countsByYear W19926675142013 @default.
• W1992667514 countsByYear W19926675142014 @default.
• W1992667514 countsByYear W19926675142016 @default.
• W1992667514 countsByYear W19926675142019 @default.
• W1992667514 countsByYear W19926675142021 @default.
• W1992667514 countsByYear W19926675142022 @default.
• W1992667514 countsByYear W19926675142023 @default.
• W1992667514 crossrefType "journal-article" @default.
• W1992667514 hasAuthorship W1992667514A5002946069 @default.
• W1992667514 hasAuthorship W1992667514A5033477493 @default.
• W1992667514 hasAuthorship W1992667514A5041414302 @default.
• W1992667514 hasAuthorship W1992667514A5043070294 @default.
• W1992667514 hasBestOaLocation W19926675141 @default.
• W1992667514 hasConcept C119062480 @default.
• W1992667514 hasConcept C158617107 @default.
• W1992667514 hasConcept C159047783 @default.
• W1992667514 hasConcept C170627219 @default.
• W1992667514 hasConcept C203014093 @default.
• W1992667514 hasConcept C207936829 @default.
• W1992667514 hasConcept C2522874641 @default.
• W1992667514 hasConcept C2908647359 @default.
• W1992667514 hasConcept C71924100 @default.
• W1992667514 hasConcept C86803240 @default.
• W1992667514 hasConcept C8891405 @default.
• W1992667514 hasConcept C95444343 @default.
• W1992667514 hasConcept C99454951 @default.
• W1992667514 hasConceptScore W1992667514C119062480 @default.
• W1992667514 hasConceptScore W1992667514C158617107 @default.
• W1992667514 hasConceptScore W1992667514C159047783 @default.
• W1992667514 hasConceptScore W1992667514C170627219 @default.
• W1992667514 hasConceptScore W1992667514C203014093 @default.
• W1992667514 hasConceptScore W1992667514C207936829 @default.
• W1992667514 hasConceptScore W1992667514C2522874641 @default.
• W1992667514 hasConceptScore W1992667514C2908647359 @default.
• W1992667514 hasConceptScore W1992667514C71924100 @default.
• W1992667514 hasConceptScore W1992667514C86803240 @default.
• W1992667514 hasConceptScore W1992667514C8891405 @default.
• W1992667514 hasConceptScore W1992667514C95444343 @default.
• W1992667514 hasConceptScore W1992667514C99454951 @default.
• W1992667514 hasIssue "1" @default.
• W1992667514 hasLocation W19926675141 @default.
• W1992667514 hasLocation W19926675142 @default.
• W1992667514 hasLocation W19926675143 @default.
• W1992667514 hasLocation W19926675144 @default.

• next