Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992680021> ?p ?o ?g. }
- W1992680021 endingPage "98" @default.
- W1992680021 startingPage "89" @default.
- W1992680021 abstract "Alcohol use during adolescence leads to increased risk of developing an alcohol use disorder (AUD) during adulthood. Converging evidence suggests that this period of enhanced vulnerability for developing an AUD may be due to the adolescent's unique sensitivity and response to alcohol. Adolescent rats have been shown to be less sensitive to alcohol intoxication and withdrawal susceptibility; however, age differences in ethanol pharmacokinetics may underlie these effects. Therefore, this study investigated alcohol intoxication behavior and withdrawal severity using a modified Majchrowicz model of alcohol dependence that has been shown to result in similar blood ethanol concentrations (BECs) despite age differences. Adolescent (postnatal day, PND, 35) and adult rats (PND 70+) received ethanol according to this 4-day binge paradigm and were observed for withdrawal behavior for 17 h. As expected, adolescents showed decreased sensitivity to alcohol-induced CNS depression as evidenced by significantly lower intoxication scores. Thus, adolescents received significantly more ethanol each day (12.3 ± 0.1 g/kg/day) than adults (9.2 ± 0.2 g/kg/day). Despite greater ethanol dosing in adolescent rats, both adolescent and adult groups had comparable peak BECs (344.5 ± 10.2 and 338.5 ± 7.8 mg/dL, respectively). Strikingly, withdrawal severity was similar quantitatively and qualitatively between adolescent and adult rats. Further, this is the first time that withdrawal behavior has been reported for adolescent rats using this model of alcohol dependence. A second experiment confirmed the similarity in BECs at various time points across the binge. These results demonstrate that after consideration of ethanol pharmacokinetics between adults and adolescents by using a model that produces similar BECs, withdrawal severity is nearly identical. This study, in combination with previous reports on ethanol withdrawal in adolescents and adults, suggests only a BEC-dependent effect of ethanol on withdrawal severity regardless of age." @default.
- W1992680021 created "2016-06-24" @default.
- W1992680021 creator A5027099876 @default.
- W1992680021 creator A5050244381 @default.
- W1992680021 creator A5067314829 @default.
- W1992680021 creator A5072436294 @default.
- W1992680021 creator A5085207528 @default.
- W1992680021 date "2010-01-01" @default.
- W1992680021 modified "2023-10-11" @default.
- W1992680021 title "Similar withdrawal severity in adolescents and adults in a rat model of alcohol dependence" @default.
- W1992680021 cites W1570708643 @default.
- W1992680021 cites W1950972906 @default.
- W1992680021 cites W1966021217 @default.
- W1992680021 cites W1972421000 @default.
- W1992680021 cites W1977996289 @default.
- W1992680021 cites W1978013837 @default.
- W1992680021 cites W1978275630 @default.
- W1992680021 cites W1982615438 @default.
- W1992680021 cites W1989156619 @default.
- W1992680021 cites W1989975279 @default.
- W1992680021 cites W1992963305 @default.
- W1992680021 cites W1997696271 @default.
- W1992680021 cites W1997723786 @default.
- W1992680021 cites W2003207057 @default.
- W1992680021 cites W2008852204 @default.
- W1992680021 cites W2011044541 @default.
- W1992680021 cites W2011628272 @default.
- W1992680021 cites W2016721926 @default.
- W1992680021 cites W2021508451 @default.
- W1992680021 cites W2036411546 @default.
- W1992680021 cites W2040474955 @default.
- W1992680021 cites W2041560839 @default.
- W1992680021 cites W2053177852 @default.
- W1992680021 cites W2057845022 @default.
- W1992680021 cites W2058180195 @default.
- W1992680021 cites W2058713706 @default.
- W1992680021 cites W2060984571 @default.
- W1992680021 cites W2062675145 @default.
- W1992680021 cites W2065361873 @default.
- W1992680021 cites W2066339999 @default.
- W1992680021 cites W2067332258 @default.
- W1992680021 cites W2067539731 @default.
- W1992680021 cites W2076264429 @default.
- W1992680021 cites W2077470362 @default.
- W1992680021 cites W2084081279 @default.
- W1992680021 cites W2087633077 @default.
- W1992680021 cites W2090520944 @default.
- W1992680021 cites W2090931660 @default.
- W1992680021 cites W2103474220 @default.
- W1992680021 cites W2144124297 @default.
- W1992680021 cites W2144967819 @default.
- W1992680021 cites W2148235068 @default.
- W1992680021 cites W2149285582 @default.
- W1992680021 cites W2166199263 @default.
- W1992680021 cites W2338719804 @default.
- W1992680021 cites W4206592573 @default.
- W1992680021 cites W4237131259 @default.
- W1992680021 doi "https://doi.org/10.1016/j.alcohol.2009.10.017" @default.
- W1992680021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2818405" @default.
- W1992680021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20113877" @default.
- W1992680021 hasPublicationYear "2010" @default.
- W1992680021 type Work @default.
- W1992680021 sameAs 1992680021 @default.
- W1992680021 citedByCount "63" @default.
- W1992680021 countsByYear W19926800212012 @default.
- W1992680021 countsByYear W19926800212013 @default.
- W1992680021 countsByYear W19926800212014 @default.
- W1992680021 countsByYear W19926800212015 @default.
- W1992680021 countsByYear W19926800212016 @default.
- W1992680021 countsByYear W19926800212017 @default.
- W1992680021 countsByYear W19926800212018 @default.
- W1992680021 countsByYear W19926800212019 @default.
- W1992680021 countsByYear W19926800212020 @default.
- W1992680021 countsByYear W19926800212021 @default.
- W1992680021 countsByYear W19926800212022 @default.
- W1992680021 countsByYear W19926800212023 @default.
- W1992680021 crossrefType "journal-article" @default.
- W1992680021 hasAuthorship W1992680021A5027099876 @default.
- W1992680021 hasAuthorship W1992680021A5050244381 @default.
- W1992680021 hasAuthorship W1992680021A5067314829 @default.
- W1992680021 hasAuthorship W1992680021A5072436294 @default.
- W1992680021 hasAuthorship W1992680021A5085207528 @default.
- W1992680021 hasBestOaLocation W19926800212 @default.
- W1992680021 hasConcept C126322002 @default.
- W1992680021 hasConcept C134018914 @default.
- W1992680021 hasConcept C139719470 @default.
- W1992680021 hasConcept C15744967 @default.
- W1992680021 hasConcept C162324750 @default.
- W1992680021 hasConcept C178790620 @default.
- W1992680021 hasConcept C185592680 @default.
- W1992680021 hasConcept C190385971 @default.
- W1992680021 hasConcept C205545832 @default.
- W1992680021 hasConcept C2776610969 @default.
- W1992680021 hasConcept C2776679223 @default.
- W1992680021 hasConcept C2776867660 @default.
- W1992680021 hasConcept C2779436514 @default.
- W1992680021 hasConcept C2779442783 @default.
- W1992680021 hasConcept C2780161600 @default.