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- W1992690239 abstract "To observe the effects of electric fields (EFs) on the migration of human retinal pigment epithelial (RPE) cells and to explore possible related mechanisms.Cultured human RPE cells were exposed to EFs, and images of the cells were obtained at regular intervals to evaluate the cell migration and viability. Distribution of F-actin and beta1 integrin was measured by immunohistochemistry. Expression of beta1 integrin was determined by PCR and Western blotting.Exposure to EFs resulted in a cathodal-directed migration of RPE cells and a cathodal accumulation of F-actin and beta1 integrin in the cells. EF stimulation increased expression of beta1 integrin both in mRNA and protein levels. These effects could be inhibited by cytochalasin B.EFs induce directed migration of RPE cells, and this effect is, to some extent, regulated by the interaction between cytoskeleton and integrins." @default.
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- W1992690239 date "2009-01-01" @default.
- W1992690239 modified "2023-10-14" @default.
- W1992690239 title "Electric Fields Contribute to Directed Migration of Human Retinal Pigment Epithelial Cells via Interaction between F-Actin and β1 Integrin" @default.
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- W1992690239 doi "https://doi.org/10.1080/02713680902879033" @default.
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