FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992690247> ?p ?o ?g. }

• W1992690247 endingPage "24" @default.
• W1992690247 startingPage "18" @default.
• W1992690247 abstract "Transgenic rat gene-mutation assays can be used to assess genotoxicity of chemicals in target organs for carcinogenicity. Since gene mutations in transgenes are genetically neutral and thus accumulate along with treatment periods, the assays are suitable for genotoxicity risk assessment of chemicals using repeated-dose treatment methodologies. However, few studies have been conducted to examine the suitability of the assays in repeat-dose treatment protocols. In order to prove the utility of the transgenic rat assays, we treated gpt delta rats with aristolochic acid at 0.3 and 1 mg/kg by gavage daily for 28 days, and autopsied the rats 3 days after the final treatment, which is a protocol recommended by the International Workshop on Genotoxicity Testing (IWGT). Aristolochic acid exists in herbs and some other plants, and is carcinogenic in the kidney, bladder and stomach in rats. The mutant frequency (MF) in both the kidney and the liver increased significantly in a dose-dependent manner when the rats were treated with aristolochic acid. We concluded that the gpt delta rat assay is sensitive enough to detect gene mutations induced by aristolochic acid and also that the 28-day repeated-dose protocol is suitable for assessing genotoxicity of chemicals." @default.
• W1992690247 created "2016-06-24" @default.
• W1992690247 creator A5011851188 @default.
• W1992690247 creator A5031224555 @default.
• W1992690247 creator A5032120247 @default.
• W1992690247 creator A5046785308 @default.
• W1992690247 creator A5068189444 @default.
• W1992690247 creator A5078829314 @default.
• W1992690247 creator A5082258899 @default.
• W1992690247 creator A5086104727 @default.
• W1992690247 creator A5087231904 @default.
• W1992690247 date "2012-01-01" @default.
• W1992690247 modified "2023-10-16" @default.
• W1992690247 title "Evaluation of the Genotoxicity of Aristolochic Acid in the Kidney and Liver of F344 gpt delta Transgenic Rat Using a 28-Day Repeated-dose Protocol: A Collaborative Study of the gpt delta Transgenic Rat Mutation Assay" @default.
• W1992690247 cites W129251135 @default.
• W1992690247 cites W1525527430 @default.
• W1992690247 cites W1975448071 @default.
• W1992690247 cites W1976243031 @default.
• W1992690247 cites W1983356876 @default.
• W1992690247 cites W1986678213 @default.
• W1992690247 cites W1990965122 @default.
• W1992690247 cites W1991095464 @default.
• W1992690247 cites W1995985392 @default.
• W1992690247 cites W2002086942 @default.
• W1992690247 cites W2045537135 @default.
• W1992690247 cites W2047801896 @default.
• W1992690247 cites W2067006694 @default.
• W1992690247 cites W2090434942 @default.
• W1992690247 cites W2121669201 @default.
• W1992690247 cites W2131288862 @default.
• W1992690247 cites W2132224561 @default.
• W1992690247 cites W2159247457 @default.
• W1992690247 cites W2162463986 @default.
• W1992690247 doi "https://doi.org/10.3123/jemsge.34.18" @default.
• W1992690247 hasPublicationYear "2012" @default.
• W1992690247 type Work @default.
• W1992690247 sameAs 1992690247 @default.
• W1992690247 citedByCount "11" @default.
• W1992690247 countsByYear W19926902472012 @default.
• W1992690247 countsByYear W19926902472013 @default.
• W1992690247 countsByYear W19926902472014 @default.
• W1992690247 countsByYear W19926902472015 @default.
• W1992690247 countsByYear W19926902472016 @default.
• W1992690247 countsByYear W19926902472017 @default.
• W1992690247 countsByYear W19926902472019 @default.
• W1992690247 countsByYear W19926902472020 @default.
• W1992690247 crossrefType "journal-article" @default.
• W1992690247 hasAuthorship W1992690247A5011851188 @default.
• W1992690247 hasAuthorship W1992690247A5031224555 @default.
• W1992690247 hasAuthorship W1992690247A5032120247 @default.
• W1992690247 hasAuthorship W1992690247A5046785308 @default.
• W1992690247 hasAuthorship W1992690247A5068189444 @default.
• W1992690247 hasAuthorship W1992690247A5078829314 @default.
• W1992690247 hasAuthorship W1992690247A5082258899 @default.
• W1992690247 hasAuthorship W1992690247A5086104727 @default.
• W1992690247 hasAuthorship W1992690247A5087231904 @default.
• W1992690247 hasBestOaLocation W19926902471 @default.
• W1992690247 hasConcept C102230213 @default.
• W1992690247 hasConcept C104317684 @default.
• W1992690247 hasConcept C114246631 @default.
• W1992690247 hasConcept C178790620 @default.
• W1992690247 hasConcept C185592680 @default.
• W1992690247 hasConcept C2778959862 @default.
• W1992690247 hasConcept C2780091579 @default.
• W1992690247 hasConcept C2780813843 @default.
• W1992690247 hasConcept C29730261 @default.
• W1992690247 hasConcept C2994225774 @default.
• W1992690247 hasConcept C33070731 @default.
• W1992690247 hasConcept C501734568 @default.
• W1992690247 hasConcept C54355233 @default.
• W1992690247 hasConcept C55493867 @default.
• W1992690247 hasConcept C86803240 @default.
• W1992690247 hasConcept C98274493 @default.
• W1992690247 hasConceptScore W1992690247C102230213 @default.
• W1992690247 hasConceptScore W1992690247C104317684 @default.
• W1992690247 hasConceptScore W1992690247C114246631 @default.
• W1992690247 hasConceptScore W1992690247C178790620 @default.
• W1992690247 hasConceptScore W1992690247C185592680 @default.
• W1992690247 hasConceptScore W1992690247C2778959862 @default.
• W1992690247 hasConceptScore W1992690247C2780091579 @default.
• W1992690247 hasConceptScore W1992690247C2780813843 @default.
• W1992690247 hasConceptScore W1992690247C29730261 @default.
• W1992690247 hasConceptScore W1992690247C2994225774 @default.
• W1992690247 hasConceptScore W1992690247C33070731 @default.
• W1992690247 hasConceptScore W1992690247C501734568 @default.
• W1992690247 hasConceptScore W1992690247C54355233 @default.
• W1992690247 hasConceptScore W1992690247C55493867 @default.
• W1992690247 hasConceptScore W1992690247C86803240 @default.
• W1992690247 hasConceptScore W1992690247C98274493 @default.
• W1992690247 hasIssue "1" @default.
• W1992690247 hasLocation W19926902471 @default.
• W1992690247 hasOpenAccess W1992690247 @default.
• W1992690247 hasPrimaryLocation W19926902471 @default.
• W1992690247 hasRelatedWork W1990965122 @default.
• W1992690247 hasRelatedWork W1992690247 @default.
• W1992690247 hasRelatedWork W2091355127 @default.
• W1992690247 hasRelatedWork W2126747530 @default.
• W1992690247 hasRelatedWork W2604710955 @default.

• next