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- W1992695304 abstract "The DAF-7/TGF-β pathway in C. elegans interprets environmental signals relayed through amphid neurons and actively inhibits dauer formation during reproductive developmental growth [1Riddle D.L. Albert P.S. Genetic and environmental regulation of dauer larva development.in: Riddle D.L. Blumental T. Meyer B. Priess J. C. elegans II. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY1997: 739-768Google Scholar, 2Savage-Dunn C. Targets of TGF β-related signaling in Caenorhabditis elegans.Cytokine Growth Factor Rev. 2001; 12: 305-312Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar]. In metazoans, the STAT pathway interprets external stimuli through regulated tyrosine phosphorylation, nuclear translocation, and gene expression [3Levy D.E. Darnell Jr., J.E. STATs: Transcriptional control and biological impact.Nat. Rev. Mol. Cell Biol. 2002; 3: 651-662Crossref PubMed Scopus (2311) Google Scholar], but its importance for developmental commitment, particularly in conjuction with TGF-β, remains largely unknown. Here, we report that the nematode STAT ortholog STA-1 accumulated in the nuclei of five head neuron pairs, three of which are amphid neurons involved in dauer formation [1Riddle D.L. Albert P.S. Genetic and environmental regulation of dauer larva development.in: Riddle D.L. Blumental T. Meyer B. Priess J. C. elegans II. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY1997: 739-768Google Scholar, 4Albert P.S. Brown S.J. Riddle D.L. Sensory control of dauer larva formation in Caenorhabditis elegans.J. Comp. Neurol. 1981; 198: 435-451Crossref PubMed Scopus (137) Google Scholar]. Moreover, sta-1 mutants showed a synthetic dauer phenotype with selected TGF-β mutations. sta-1 deficiency was complemented by reconstitution with wild-type protein, but not with a tyrosine mutant. Canonical TGF-β signaling involves the DAF-7/TGF-β ligand activating the DAF-1/DAF-4 receptor pair to regulate the DAF-8/DAF-14 Smads [5Patterson G.I. Koweek A. Wong A. Liu Y. Ruvkun G. The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegans dauer pathway.Genes Dev. 1997; 11: 2679-2690Crossref PubMed Scopus (154) Google Scholar]. Interestingly, STA-1 functioned in the absence of DAF-7, DAF-4, and DAF-14, but it required DAF-1 and DAF-8. Additionally, STA-1 expression was induced by TGF-β in a DAF-3-dependent manner, demonstrating a homeostatic negative feedback loop. These results highlight a role for activated STAT proteins in repression of dauer formation. They also raise the possibility of an unexpected function for DAF-1 and DAF-8 that is independent of their normal upstream activator, DAF-7." @default.
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- W1992695304 date "2006-01-01" @default.
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- W1992695304 title "C. elegans STAT Cooperates with DAF-7/TGF-β Signaling to Repress Dauer Formation" @default.
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- W1992695304 doi "https://doi.org/10.1016/j.cub.2005.11.061" @default.
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