FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992718045> ?p ?o ?g. }

• W1992718045 endingPage "7783" @default.
• W1992718045 startingPage "7775" @default.
• W1992718045 abstract "The apolipoprotein (APOE) ε4 allele is a strong genetic risk factor for Alzheimer's disease (AD). Intrinsic fluctuations of brain activity measured by fMRI during rest may be sensitive to AD-related neuropathology. In particular, functional connectivity of the default-mode network (DMN) has gained recent attention as a possible biomarker of disease processes and associated memory decline in AD. Here, we tested the hypothesis of APOE-related alterations in DMN functional connectivity in 95 healthy individuals between 50 and 80 years of age, including 33 carriers of the ε4 allele. Based on previous studies, we hypothesized increased hippocampal DMN synchronization in APOE ε4 carriers. This was supported using independent component analysis in combination with a dual-regression approach for analysis of resting state data. Whole-brain analysis suggested effects also in other areas, including the posterior cingulate cortex, parietal cortex, and parahippocampal regions. DMN synchronization showed a negative correlation with performance on a test of memory functioning, suggesting a neurocognitive significance of the brain activity patterns during rest. Our findings indicate that increased genetic vulnerability for AD is reflected in increased hippocampal DMN synchronization during rest several years before clinical manifestation. We propose that the results reflect ε4-related failure in hippocampal decoupling, which might elevate the total hippocampal metabolic burden and increase the risk of cognitive decline and AD. The results provide an important confirmation of specific genotype effects on intrinsic fluctuations and support the use of functional connectivity indices as imaging-derived endophenotypes in the emerging field of imaging genetics." @default.
• W1992718045 created "2016-06-24" @default.
• W1992718045 creator A5036064271 @default.
• W1992718045 creator A5039481143 @default.
• W1992718045 creator A5056629578 @default.
• W1992718045 creator A5060325633 @default.
• W1992718045 creator A5089076382 @default.
• W1992718045 date "2011-05-25" @default.
• W1992718045 modified "2023-10-12" @default.
• W1992718045 title "Increased Hippocampal Default Mode Synchronization during Rest in Middle-Aged and Elderly APOE ε4 Carriers: Relationships with Memory Performance" @default.
• W1992718045 cites W148236777 @default.
• W1992718045 cites W1760829075 @default.
• W1992718045 cites W1847168837 @default.
• W1992718045 cites W1964634864 @default.
• W1992718045 cites W1964793333 @default.
• W1992718045 cites W1965780119 @default.
• W1992718045 cites W1970866005 @default.
• W1992718045 cites W1973932627 @default.
• W1992718045 cites W1974594322 @default.
• W1992718045 cites W1990121924 @default.
• W1992718045 cites W1996142279 @default.
• W1992718045 cites W1997298866 @default.
• W1992718045 cites W1997301424 @default.
• W1992718045 cites W2002610924 @default.
• W1992718045 cites W2002923643 @default.
• W1992718045 cites W2004293194 @default.
• W1992718045 cites W2005246739 @default.
• W1992718045 cites W2006096283 @default.
• W1992718045 cites W2007572953 @default.
• W1992718045 cites W2009494091 @default.
• W1992718045 cites W2016128925 @default.
• W1992718045 cites W2017079501 @default.
• W1992718045 cites W2017395555 @default.
• W1992718045 cites W2018523864 @default.
• W1992718045 cites W2023121717 @default.
• W1992718045 cites W2027781650 @default.
• W1992718045 cites W2029151785 @default.
• W1992718045 cites W2031425398 @default.
• W1992718045 cites W2033987011 @default.
• W1992718045 cites W2036717027 @default.
• W1992718045 cites W2037557484 @default.
• W1992718045 cites W2041325253 @default.
• W1992718045 cites W2046557060 @default.
• W1992718045 cites W2052644075 @default.
• W1992718045 cites W2052742260 @default.
• W1992718045 cites W2060492349 @default.
• W1992718045 cites W2062843923 @default.
• W1992718045 cites W2069121057 @default.
• W1992718045 cites W2070949043 @default.
• W1992718045 cites W2079450984 @default.
• W1992718045 cites W2093972428 @default.
• W1992718045 cites W2095642798 @default.
• W1992718045 cites W2102263312 @default.
• W1992718045 cites W2104850453 @default.
• W1992718045 cites W2105086806 @default.
• W1992718045 cites W2107360535 @default.
• W1992718045 cites W2110208125 @default.
• W1992718045 cites W2111175305 @default.
• W1992718045 cites W2112518510 @default.
• W1992718045 cites W2114267373 @default.
• W1992718045 cites W2114555409 @default.
• W1992718045 cites W2115738813 @default.
• W1992718045 cites W2117621792 @default.
• W1992718045 cites W2121101037 @default.
• W1992718045 cites W2121369614 @default.
• W1992718045 cites W2133903921 @default.
• W1992718045 cites W2136435696 @default.
• W1992718045 cites W2136573752 @default.
• W1992718045 cites W2137526583 @default.
• W1992718045 cites W2138790588 @default.
• W1992718045 cites W2138905229 @default.
• W1992718045 cites W2139851615 @default.
• W1992718045 cites W2140074909 @default.
• W1992718045 cites W2143285014 @default.
• W1992718045 cites W2148726987 @default.
• W1992718045 cites W2150177485 @default.
• W1992718045 cites W2150652656 @default.
• W1992718045 cites W2151721316 @default.
• W1992718045 cites W2155963684 @default.
• W1992718045 cites W2157270343 @default.
• W1992718045 cites W2157848968 @default.
• W1992718045 cites W2158031492 @default.
• W1992718045 cites W2158592797 @default.
• W1992718045 cites W2158611196 @default.
• W1992718045 cites W2158945984 @default.
• W1992718045 cites W2162010696 @default.
• W1992718045 cites W2164303459 @default.
• W1992718045 cites W2167720733 @default.
• W1992718045 cites W2912570166 @default.
• W1992718045 doi "https://doi.org/10.1523/jneurosci.1230-11.2011" @default.
• W1992718045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6633142" @default.
• W1992718045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21613490" @default.
• W1992718045 hasPublicationYear "2011" @default.
• W1992718045 type Work @default.
• W1992718045 sameAs 1992718045 @default.
• W1992718045 citedByCount "159" @default.
• W1992718045 countsByYear W19927180452012 @default.
• W1992718045 countsByYear W19927180452013 @default.

• next