FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992741385> ?p ?o ?g. }

• W1992741385 endingPage "42" @default.
• W1992741385 startingPage "33" @default.
• W1992741385 abstract "Ferredoxin reductase (FDXR, also known as adrenodoxin reductase) is a mitochondrial flavoprotein that transfers electrons from NADPH to mitochondrial cytochrome P450 enzymes, mediating the function of an iron-sulfur cluster protein, ferredoxin. FDXR functions in various metabolic processes including steroidogenesis. It is well known that multiple steroidogenic enzymes are regulated by a transcription factor steroidogenic factor-1 (SF-1, also known as Ad4BP). Previously, we have shown that SF-1 transduction causes human mesenchymal stem cell differentiation into steroidogenic cells. Genome-wide analysis of differentiated cells, using a combination of DNA microarray and promoter tiling array analyses, showed that FDXR is a novel SF-1 target gene. In this study, the transcriptional regulatory mechanism of FDXR was examined in steroidogenic cells. A chromatin immunoprecipitation assay revealed that a novel SF-1 binding region was located within intron 2 of the human FDXR gene. Luciferase reporter assays showed that FDXR transcription was activated through the novel SF-1 binding site within intron 2. Endogenous SF-1 knockdown in human adrenocortical H295R and KGN cells decreased FDXR expression. In H295R cells, strong binding of two histone markers of active enhancers, histones H3K27ac and H3K4me2, were detected near the SF-1 binding site within intron 2. Furthermore, the binding of these histone markers was decreased concurrent with SF-1 knockdown in H295R cells. These results indicated that abundant FDXR expression in these steroidogenic cells was maintained through SF-1 binding to the intronic enhancer of the FDXR gene." @default.
• W1992741385 created "2016-06-24" @default.
• W1992741385 creator A5007629809 @default.
• W1992741385 creator A5010631611 @default.
• W1992741385 creator A5019599849 @default.
• W1992741385 creator A5034960930 @default.
• W1992741385 creator A5050928064 @default.
• W1992741385 creator A5057181431 @default.
• W1992741385 creator A5089649911 @default.
• W1992741385 creator A5091576618 @default.
• W1992741385 date "2014-01-01" @default.
• W1992741385 modified "2023-10-17" @default.
• W1992741385 title "Transcriptional regulation of human ferredoxin reductase through an intronic enhancer in steroidogenic cells" @default.
• W1992741385 cites W1537702562 @default.
• W1992741385 cites W1577584933 @default.
• W1992741385 cites W1863838411 @default.
• W1992741385 cites W1963827257 @default.
• W1992741385 cites W1968355797 @default.
• W1992741385 cites W1981030303 @default.
• W1992741385 cites W1987207574 @default.
• W1992741385 cites W1987704635 @default.
• W1992741385 cites W1997377831 @default.
• W1992741385 cites W2005573622 @default.
• W1992741385 cites W2023070199 @default.
• W1992741385 cites W2025341818 @default.
• W1992741385 cites W2031212222 @default.
• W1992741385 cites W2031714657 @default.
• W1992741385 cites W2035916213 @default.
• W1992741385 cites W2050345313 @default.
• W1992741385 cites W2067421493 @default.
• W1992741385 cites W2077806118 @default.
• W1992741385 cites W2083105212 @default.
• W1992741385 cites W2100859941 @default.
• W1992741385 cites W2106876536 @default.
• W1992741385 cites W2110919070 @default.
• W1992741385 cites W2123126118 @default.
• W1992741385 cites W2123564569 @default.
• W1992741385 cites W2126846194 @default.
• W1992741385 cites W2136357797 @default.
• W1992741385 cites W2142216509 @default.
• W1992741385 cites W2147022658 @default.
• W1992741385 cites W2147452643 @default.
• W1992741385 cites W2153154875 @default.
• W1992741385 cites W2154591315 @default.
• W1992741385 cites W4210994334 @default.
• W1992741385 doi "https://doi.org/10.1016/j.bbagrm.2013.11.005" @default.
• W1992741385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24321386" @default.
• W1992741385 hasPublicationYear "2014" @default.
• W1992741385 type Work @default.
• W1992741385 sameAs 1992741385 @default.
• W1992741385 citedByCount "20" @default.
• W1992741385 countsByYear W19927413852014 @default.
• W1992741385 countsByYear W19927413852015 @default.
• W1992741385 countsByYear W19927413852016 @default.
• W1992741385 countsByYear W19927413852017 @default.
• W1992741385 countsByYear W19927413852018 @default.
• W1992741385 countsByYear W19927413852019 @default.
• W1992741385 countsByYear W19927413852020 @default.
• W1992741385 countsByYear W19927413852021 @default.
• W1992741385 countsByYear W19927413852022 @default.
• W1992741385 countsByYear W19927413852023 @default.
• W1992741385 crossrefType "journal-article" @default.
• W1992741385 hasAuthorship W1992741385A5007629809 @default.
• W1992741385 hasAuthorship W1992741385A5010631611 @default.
• W1992741385 hasAuthorship W1992741385A5019599849 @default.
• W1992741385 hasAuthorship W1992741385A5034960930 @default.
• W1992741385 hasAuthorship W1992741385A5050928064 @default.
• W1992741385 hasAuthorship W1992741385A5057181431 @default.
• W1992741385 hasAuthorship W1992741385A5089649911 @default.
• W1992741385 hasAuthorship W1992741385A5091576618 @default.
• W1992741385 hasConcept C101762097 @default.
• W1992741385 hasConcept C104317684 @default.
• W1992741385 hasConcept C111936080 @default.
• W1992741385 hasConcept C134320426 @default.
• W1992741385 hasConcept C134621786 @default.
• W1992741385 hasConcept C150194340 @default.
• W1992741385 hasConcept C153911025 @default.
• W1992741385 hasConcept C173396325 @default.
• W1992741385 hasConcept C181199279 @default.
• W1992741385 hasConcept C2777703421 @default.
• W1992741385 hasConcept C55493867 @default.
• W1992741385 hasConcept C63932345 @default.
• W1992741385 hasConcept C83640560 @default.
• W1992741385 hasConcept C86339819 @default.
• W1992741385 hasConcept C86803240 @default.
• W1992741385 hasConceptScore W1992741385C101762097 @default.
• W1992741385 hasConceptScore W1992741385C104317684 @default.
• W1992741385 hasConceptScore W1992741385C111936080 @default.
• W1992741385 hasConceptScore W1992741385C134320426 @default.
• W1992741385 hasConceptScore W1992741385C134621786 @default.
• W1992741385 hasConceptScore W1992741385C150194340 @default.
• W1992741385 hasConceptScore W1992741385C153911025 @default.
• W1992741385 hasConceptScore W1992741385C173396325 @default.
• W1992741385 hasConceptScore W1992741385C181199279 @default.
• W1992741385 hasConceptScore W1992741385C2777703421 @default.
• W1992741385 hasConceptScore W1992741385C55493867 @default.
• W1992741385 hasConceptScore W1992741385C63932345 @default.
• W1992741385 hasConceptScore W1992741385C83640560 @default.

• next