Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992743531> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1992743531 abstract "The purpose of this study was to examine the influence of altered prednisolone kinetics in patients with the nephrotic syndrome and women taking oral contraceptive steroids on mixed lymphocyte cultures (MLC). After oral and iv prednisolone treatment, blood samples were collected over 24 h. The area under the plasma concentration vs. time curve (AUC) of unbound, transcortin- bound, and albumin-bound prednisolone was determined. All plasma samples were incubated with MLCs, and the area under the inhibition vs. time curve of the MLC (AUIC), a measure of the effect over time, was calculated. The steroid concentrations required to produce half-maximal inhibition (EC50) were calculated. The 10 women taking oral contraceptives had higher AUCs of unbound and transcortin-bound prednisolone than the 10 normal subjects. The mean biological effect (AUIC value) was more pronounced in women taking contraceptive steroids. An analysis of the concentration-response curves revealed that the EC50 values of total, but not unbound, prednisolone were higher in women taking contraceptives. Compared with the normal subjects, the 9 nephrotic patients had lower total and comparable unbound AUCs of prednisolone. The AUIC values were higher whereas the EC50 values of unbound and total prednisolone were lower in the nephrotic patients. These findings indicate that the increased steroid effect in women taking oral contraceptives is explained by higher concentrations of prednisolone, while the increased effect in nephrotic patients is not attributable to the abnormal kinetics or protein binding of prednisolone." @default.
- W1992743531 created "2016-06-24" @default.
- W1992743531 creator A5051282495 @default.
- W1992743531 creator A5077967152 @default.
- W1992743531 date "1985-02-01" @default.
- W1992743531 modified "2023-09-25" @default.
- W1992743531 title "The Effect of Altered Prednisolone Kinetics in Patients with the Nephrotic Syndrome and in Women Taking Oral Contraceptive Steroids on Human Mixed Lymphocyte Cultures" @default.
- W1992743531 cites W1538795472 @default.
- W1992743531 cites W1601102387 @default.
- W1992743531 cites W1669751253 @default.
- W1992743531 cites W1929728303 @default.
- W1992743531 cites W1952999084 @default.
- W1992743531 cites W1969399021 @default.
- W1992743531 cites W1974378609 @default.
- W1992743531 cites W1975957728 @default.
- W1992743531 cites W1981567795 @default.
- W1992743531 cites W1987076542 @default.
- W1992743531 cites W1995993817 @default.
- W1992743531 cites W1997415403 @default.
- W1992743531 cites W1999041073 @default.
- W1992743531 cites W2001176043 @default.
- W1992743531 cites W2008282647 @default.
- W1992743531 cites W2008777875 @default.
- W1992743531 cites W2021717422 @default.
- W1992743531 cites W2029721657 @default.
- W1992743531 cites W2031922967 @default.
- W1992743531 cites W2031968001 @default.
- W1992743531 cites W2035412364 @default.
- W1992743531 cites W2043669686 @default.
- W1992743531 cites W2052135716 @default.
- W1992743531 cites W2054199251 @default.
- W1992743531 cites W2056939792 @default.
- W1992743531 cites W2061533021 @default.
- W1992743531 cites W2065275824 @default.
- W1992743531 cites W2076740622 @default.
- W1992743531 cites W2079415759 @default.
- W1992743531 cites W2080008016 @default.
- W1992743531 cites W2083619892 @default.
- W1992743531 cites W2099929626 @default.
- W1992743531 cites W2108418459 @default.
- W1992743531 cites W2113626910 @default.
- W1992743531 cites W2140497896 @default.
- W1992743531 cites W2156844985 @default.
- W1992743531 cites W2167404430 @default.
- W1992743531 cites W2225031403 @default.
- W1992743531 cites W2305284279 @default.
- W1992743531 cites W2409540793 @default.
- W1992743531 cites W2437293134 @default.
- W1992743531 cites W2470004569 @default.
- W1992743531 cites W2607269607 @default.
- W1992743531 cites W35884303 @default.
- W1992743531 cites W78466469 @default.
- W1992743531 doi "https://doi.org/10.1210/jcem-60-2-361" @default.
- W1992743531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3155524" @default.
- W1992743531 hasPublicationYear "1985" @default.
- W1992743531 type Work @default.
- W1992743531 sameAs 1992743531 @default.
- W1992743531 citedByCount "23" @default.
- W1992743531 countsByYear W19927435312017 @default.
- W1992743531 crossrefType "journal-article" @default.
- W1992743531 hasAuthorship W1992743531A5051282495 @default.
- W1992743531 hasAuthorship W1992743531A5077967152 @default.
- W1992743531 hasConcept C126322002 @default.
- W1992743531 hasConcept C134018914 @default.
- W1992743531 hasConcept C185592680 @default.
- W1992743531 hasConcept C2776715498 @default.
- W1992743531 hasConcept C2778930706 @default.
- W1992743531 hasConcept C71924100 @default.
- W1992743531 hasConcept C81358767 @default.
- W1992743531 hasConcept C90134679 @default.
- W1992743531 hasConceptScore W1992743531C126322002 @default.
- W1992743531 hasConceptScore W1992743531C134018914 @default.
- W1992743531 hasConceptScore W1992743531C185592680 @default.
- W1992743531 hasConceptScore W1992743531C2776715498 @default.
- W1992743531 hasConceptScore W1992743531C2778930706 @default.
- W1992743531 hasConceptScore W1992743531C71924100 @default.
- W1992743531 hasConceptScore W1992743531C81358767 @default.
- W1992743531 hasConceptScore W1992743531C90134679 @default.
- W1992743531 hasLocation W19927435311 @default.
- W1992743531 hasLocation W19927435312 @default.
- W1992743531 hasOpenAccess W1992743531 @default.
- W1992743531 hasPrimaryLocation W19927435311 @default.
- W1992743531 hasRelatedWork W1969714037 @default.
- W1992743531 hasRelatedWork W1971392792 @default.
- W1992743531 hasRelatedWork W2019289923 @default.
- W1992743531 hasRelatedWork W2035305517 @default.
- W1992743531 hasRelatedWork W2065100475 @default.
- W1992743531 hasRelatedWork W2078881023 @default.
- W1992743531 hasRelatedWork W2090749641 @default.
- W1992743531 hasRelatedWork W2101093530 @default.
- W1992743531 hasRelatedWork W2150365860 @default.
- W1992743531 hasRelatedWork W2170987494 @default.
- W1992743531 isParatext "false" @default.
- W1992743531 isRetracted "false" @default.
- W1992743531 magId "1992743531" @default.
- W1992743531 workType "article" @default.