Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992748682> ?p ?o ?g. }
- W1992748682 endingPage "257" @default.
- W1992748682 startingPage "251" @default.
- W1992748682 abstract "We evaluated the protective efficacy of nasal atropine methyl bromide (AMB) which does not cross the blood–brain barrier against sarin inhalation exposure. Age and weight matched male guinea pigs were exposed to 846.5 mg/m3 sarin using a microinstillation inhalation exposure technique for 4 min. The survival rate at this dose was 20%. Post-exposure treatment with nasal AMB (2.5 mg/kg, 1 min) completely protected against sarin induced toxicity (100% survival). Development of muscular tremors was decreased in animals treated with nasal AMB. Post-exposure treatment with nasal AMB also normalized acute decrease in blood oxygen saturation and heart rate following sarin exposure. Inhibition of blood AChE and BChE activities following sarin exposure was reduced in animals treated with nasal AMB, indicating that survival increases the metabolism of sarin or expression of AChE. The body weight loss of animals exposed to sarin and treated with nasal AMB was similar to saline controls. No differences were observed in lung accessory lobe or tracheal edema following exposure to sarin and subsequent treatment with nasal AMB. Total bronchoalveolar lavage fluid (BALF) protein, a biomarker of lung injury, showed trends similar to saline controls. Surfactant levels post-exposure treatment with nasal AMB returned to normal, similar to saline controls. Alkaline phosphatase levels post-exposure treatment with nasal AMB were decreased. Taken together, these data suggest that nasal AMB blocks the copious airway secretion and peripheral cholinergic effects and protects against lethal inhalation exposure to sarin thus increasing survival." @default.
- W1992748682 created "2016-06-24" @default.
- W1992748682 creator A5006692660 @default.
- W1992748682 creator A5017819842 @default.
- W1992748682 creator A5029176560 @default.
- W1992748682 creator A5035700775 @default.
- W1992748682 creator A5043530377 @default.
- W1992748682 creator A5067161115 @default.
- W1992748682 creator A5071849446 @default.
- W1992748682 creator A5075779683 @default.
- W1992748682 creator A5079151109 @default.
- W1992748682 creator A5083719662 @default.
- W1992748682 creator A5089131205 @default.
- W1992748682 date "2009-09-15" @default.
- W1992748682 modified "2023-10-17" @default.
- W1992748682 title "Post-exposure treatment with nasal atropine methyl bromide protects against microinstillation inhalation exposure to sarin in guinea pigs" @default.
- W1992748682 cites W1544498307 @default.
- W1992748682 cites W15920332 @default.
- W1992748682 cites W1971048984 @default.
- W1992748682 cites W1972986411 @default.
- W1992748682 cites W1977982553 @default.
- W1992748682 cites W1982553044 @default.
- W1992748682 cites W1987492950 @default.
- W1992748682 cites W1991602762 @default.
- W1992748682 cites W1992240141 @default.
- W1992748682 cites W1994811601 @default.
- W1992748682 cites W2003343310 @default.
- W1992748682 cites W2004223808 @default.
- W1992748682 cites W2005263795 @default.
- W1992748682 cites W2006205254 @default.
- W1992748682 cites W2007932933 @default.
- W1992748682 cites W2009077259 @default.
- W1992748682 cites W2013540583 @default.
- W1992748682 cites W2017929879 @default.
- W1992748682 cites W2017969509 @default.
- W1992748682 cites W2027759920 @default.
- W1992748682 cites W2030115611 @default.
- W1992748682 cites W2037962469 @default.
- W1992748682 cites W2041190201 @default.
- W1992748682 cites W2046961891 @default.
- W1992748682 cites W2046971400 @default.
- W1992748682 cites W2049743682 @default.
- W1992748682 cites W2069832212 @default.
- W1992748682 cites W2072988210 @default.
- W1992748682 cites W2074844393 @default.
- W1992748682 cites W2080195547 @default.
- W1992748682 cites W2110740625 @default.
- W1992748682 cites W2114328797 @default.
- W1992748682 cites W2121715727 @default.
- W1992748682 cites W2136573666 @default.
- W1992748682 cites W2138702835 @default.
- W1992748682 cites W2139232904 @default.
- W1992748682 cites W2142410338 @default.
- W1992748682 cites W2155644066 @default.
- W1992748682 cites W2162245644 @default.
- W1992748682 cites W2186953423 @default.
- W1992748682 cites W2261201753 @default.
- W1992748682 cites W2281874681 @default.
- W1992748682 cites W2411922361 @default.
- W1992748682 cites W2416442375 @default.
- W1992748682 cites W65572115 @default.
- W1992748682 doi "https://doi.org/10.1016/j.taap.2009.06.002" @default.
- W1992748682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19523969" @default.
- W1992748682 hasPublicationYear "2009" @default.
- W1992748682 type Work @default.
- W1992748682 sameAs 1992748682 @default.
- W1992748682 citedByCount "11" @default.
- W1992748682 countsByYear W19927486822012 @default.
- W1992748682 countsByYear W19927486822016 @default.
- W1992748682 countsByYear W19927486822017 @default.
- W1992748682 countsByYear W19927486822019 @default.
- W1992748682 crossrefType "journal-article" @default.
- W1992748682 hasAuthorship W1992748682A5006692660 @default.
- W1992748682 hasAuthorship W1992748682A5017819842 @default.
- W1992748682 hasAuthorship W1992748682A5029176560 @default.
- W1992748682 hasAuthorship W1992748682A5035700775 @default.
- W1992748682 hasAuthorship W1992748682A5043530377 @default.
- W1992748682 hasAuthorship W1992748682A5067161115 @default.
- W1992748682 hasAuthorship W1992748682A5071849446 @default.
- W1992748682 hasAuthorship W1992748682A5075779683 @default.
- W1992748682 hasAuthorship W1992748682A5079151109 @default.
- W1992748682 hasAuthorship W1992748682A5083719662 @default.
- W1992748682 hasAuthorship W1992748682A5089131205 @default.
- W1992748682 hasConcept C126322002 @default.
- W1992748682 hasConcept C181199279 @default.
- W1992748682 hasConcept C185592680 @default.
- W1992748682 hasConcept C2775859210 @default.
- W1992748682 hasConcept C2776954882 @default.
- W1992748682 hasConcept C2777714996 @default.
- W1992748682 hasConcept C2777961210 @default.
- W1992748682 hasConcept C2778816929 @default.
- W1992748682 hasConcept C2779777708 @default.
- W1992748682 hasConcept C2780292010 @default.
- W1992748682 hasConcept C29730261 @default.
- W1992748682 hasConcept C31896038 @default.
- W1992748682 hasConcept C42219234 @default.
- W1992748682 hasConcept C55493867 @default.
- W1992748682 hasConcept C71924100 @default.