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• W1992755085 abstract "Abstract Thirty-nine cases with small cell lung carcinoma (S.C.L.C.) who were treated with radiation therapy and/or chemotherapy were analyzed retrospectively. All patients had limited disease. Mean age of the cases was 58 years. Thirty-six patients were male (92%). The most commonly seen initial symptoms were cough (72%), pleural pain (44%), dyspnea (36%), hemoptysis (28%) and fatigue (28%). Diagnosis was made by sputum cytology in 16 cases (41%), by bronchoscopy in 12 cases (31%). Seventeen cases were treated with chemotherapy alone and nineteen with combined modality. Radiation therapy was administered either concomitantly with multi-agent chemotherapy (concurrent), or after multi-agent chemotherapy (post-chemotherapy), or in between the cycles of multi-agent chemotherapy. These patients also received one of the combinations of Vp16-P, CAV, Vp16-PCc, CVCc, AVBMVp16 or Vp16-P/CAV. Patients in chemotherapy alone group received Vp16-P or CAV combinations. In the chemotherapy alone group, seven patients had a complete response (CR, 41%) and six had partial response (PR, 35%). In the combined modality group, the CR rate was 63% and the PR rate 26% (p=0.11). There was no correlation between the CR rate and total radiation dose or radiation dose per fraction (p=0.33 and 0.28). No correlation was found between the multi-agent chemotherapy regimens and the CR rate (p=0.25). Median survival in chemotherapy alone group was 7.5 months and 9.0 months in the combined modality treatment group. Overall complication rate in the chemotherapy alone group was 12% ( 2 17 ) while it was 32% ( 6 19 ) in the combined modality group (p=0.12). Distant metastasis rates were 29% and 21%, respectively. It is concluded that the addition of radiation therapy to multi-agent chemotherapy may be of some benefit in terms of complete response rates without any significant increase in complications but well-designed, prospective, randomized, controlled studies are needed to assess the role of radiation therapy in terms of local control and overall survival and optimal treatment schedules." @default.
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• W1992755085 date "1992-10-01" @default.
• W1992755085 modified "2023-10-17" @default.
• W1992755085 title "Comparison of combined modality (chemoradiotherapy) with chemotherapy alone in small cell lung carcinoma" @default.
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• W1992755085 doi "https://doi.org/10.1016/0169-5002(92)90003-3" @default.
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