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• W1992767029 abstract "Starting from the evidence that surgical treatment of the axilla does not in itself improve the survival of patients with small size breast cancer (<12 mm), and that the removal of clinically uninvolved axillery nodes is thus purely informative, we have designed a multicentric study on patients ≤45 years of age with clinically NO breast cancer, 12 mm or less; the aim is to determine whether radiotherapy (RT) to the axilla reduces the risk of late appearance of nodal metastases. Patients treated by classic quadrantectomy without axillary dissection are being randomized to two arms: one receives RT to the breast only, and the second receives RT to breast (50 Gy + 10 Gy boost) and the axilla (50 Gy). The trial started on February 1st, 1995 and at 30th January 1996, 56 patiants had been enrolled: 22 received RT to the axilla and 29 to the breast only. Of the 48 petients operated on at the EIO, 5 had a tumor ≤5 mm, 41 between 6–10 mm and 2=11 mm. The proliferative index (Ki67) was <20% in 25 patients, and tumor grading was G1 in 23 patients, G2 in 20 and G3 in 5. In the absence of lymph node information, tumor grading, hormonal receptor status and proliferative were chosen to decide adjuvant treatment. Forty one patients received hormonotharapy, 2 chemotherapy and 5 no therapy. To achieve a statistical power of 80% at least 300 women will have to be randomized over 3 years and followed for a further 8 years. Also participating are the Rome, Parma, Florence, Naples and Turin centres of the Italian Senological Oncology Group (GrISO). Starting from the evidence that surgical treatment of the axilla does not in itself improve the survival of patients with small size breast cancer (<12 mm), and that the removal of clinically uninvolved axillery nodes is thus purely informative, we have designed a multicentric study on patients ≤45 years of age with clinically NO breast cancer, 12 mm or less; the aim is to determine whether radiotherapy (RT) to the axilla reduces the risk of late appearance of nodal metastases. Patients treated by classic quadrantectomy without axillary dissection are being randomized to two arms: one receives RT to the breast only, and the second receives RT to breast (50 Gy + 10 Gy boost) and the axilla (50 Gy). The trial started on February 1st, 1995 and at 30th January 1996, 56 patiants had been enrolled: 22 received RT to the axilla and 29 to the breast only. Of the 48 petients operated on at the EIO, 5 had a tumor ≤5 mm, 41 between 6–10 mm and 2=11 mm. The proliferative index (Ki67) was <20% in 25 patients, and tumor grading was G1 in 23 patients, G2 in 20 and G3 in 5. In the absence of lymph node information, tumor grading, hormonal receptor status and proliferative were chosen to decide adjuvant treatment. Forty one patients received hormonotharapy, 2 chemotherapy and 5 no therapy. To achieve a statistical power of 80% at least 300 women will have to be randomized over 3 years and followed for a further 8 years. Also participating are the Rome, Parma, Florence, Naples and Turin centres of the Italian Senological Oncology Group (GrISO)." @default.
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• W1992767029 date "1996-01-01" @default.
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• W1992767029 title "130 P - Breast conservation without axillary dissection" @default.
• W1992767029 doi "https://doi.org/10.1016/0959-8049(96)84884-2" @default.
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