Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992769744> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1992769744 endingPage "176" @default.
- W1992769744 startingPage "170" @default.
- W1992769744 abstract "Clinical depression is a chronic, recurrent mood disorder that causes significant disability and disease burden throughout the world. Not surprisingly, there is an enormous demand for finding (a) appropriate medications and devices for treating the clinical symptoms and (b) the underlying molecular mechanisms of the disease. Currently, most therapeutic treatments of depression indirectly target the serotonin and norepinephrine systems of the brain, as these neurotransmitters have long been considered promising and mechanistically relevant to the etiology of mood disorders. However, selective serotonin reuptake inhibitors such as sertraline, fluoxetine and paroxetine do not always substantially improve clinical outcome, and when they do show efficacy, it takes weeks of treatment to achieve an appreciable clinical effect. These observations suggest that a serotonin and norepinephrine hypothesis of depression is incomplete at best, and that novel, rapid onset therapeutic options for depression must be considered. In this review, we highlight several potential new drugs for clinical depression based on recent discoveries about the neurotransmitter glutamate and its family of receptors. Moreover, we discuss the possibility that glutamate-based antidepressant drugs might affect covalent histone modifications including acetylation in areas of the brain (e.g., pre-frontal cortex, hippocampus) thought to be relevant for the pathogenesis of affective disorders. If so, histone hyperacetylation and thus chromatin remodeling might be important regulatory mechanisms underlying the effects of ketamine and other N-Methyl-D-Aspartate receptor antagonist drugs. Chromatin remodeling may represent a non-serotonin/norepinephrine therapeutic strategy for treatment of clinical depression, a strategy that may also be appropriate in the context of drug discovery and drug development. Keywords: Chromatin, epigenesis, hippocampus, histones, ketamine, N-methyl-D-aspartate receptors, pre-frontal cortex" @default.
- W1992769744 created "2016-06-24" @default.
- W1992769744 creator A5001636109 @default.
- W1992769744 creator A5005513224 @default.
- W1992769744 creator A5011208068 @default.
- W1992769744 creator A5042525428 @default.
- W1992769744 creator A5055856849 @default.
- W1992769744 creator A5061133239 @default.
- W1992769744 creator A5062743722 @default.
- W1992769744 creator A5073835551 @default.
- W1992769744 date "2008-09-01" @default.
- W1992769744 modified "2023-10-18" @default.
- W1992769744 title "Glutamate-Based Drugs for the Treatment of Clinical Depression" @default.
- W1992769744 doi "https://doi.org/10.2174/187152408785699604" @default.
- W1992769744 hasPublicationYear "2008" @default.
- W1992769744 type Work @default.
- W1992769744 sameAs 1992769744 @default.
- W1992769744 citedByCount "3" @default.
- W1992769744 countsByYear W19927697442013 @default.
- W1992769744 crossrefType "journal-article" @default.
- W1992769744 hasAuthorship W1992769744A5001636109 @default.
- W1992769744 hasAuthorship W1992769744A5005513224 @default.
- W1992769744 hasAuthorship W1992769744A5011208068 @default.
- W1992769744 hasAuthorship W1992769744A5042525428 @default.
- W1992769744 hasAuthorship W1992769744A5055856849 @default.
- W1992769744 hasAuthorship W1992769744A5061133239 @default.
- W1992769744 hasAuthorship W1992769744A5062743722 @default.
- W1992769744 hasAuthorship W1992769744A5073835551 @default.
- W1992769744 hasConcept C118552586 @default.
- W1992769744 hasConcept C126322002 @default.
- W1992769744 hasConcept C151730666 @default.
- W1992769744 hasConcept C15744967 @default.
- W1992769744 hasConcept C169760540 @default.
- W1992769744 hasConcept C170493617 @default.
- W1992769744 hasConcept C2775864247 @default.
- W1992769744 hasConcept C2776134451 @default.
- W1992769744 hasConcept C2776219046 @default.
- W1992769744 hasConcept C2777134132 @default.
- W1992769744 hasConcept C2777828372 @default.
- W1992769744 hasConcept C2778514916 @default.
- W1992769744 hasConcept C2779177272 @default.
- W1992769744 hasConcept C2779343474 @default.
- W1992769744 hasConcept C2781161787 @default.
- W1992769744 hasConcept C31487548 @default.
- W1992769744 hasConcept C513476851 @default.
- W1992769744 hasConcept C558461103 @default.
- W1992769744 hasConcept C60644358 @default.
- W1992769744 hasConcept C71924100 @default.
- W1992769744 hasConcept C86803240 @default.
- W1992769744 hasConceptScore W1992769744C118552586 @default.
- W1992769744 hasConceptScore W1992769744C126322002 @default.
- W1992769744 hasConceptScore W1992769744C151730666 @default.
- W1992769744 hasConceptScore W1992769744C15744967 @default.
- W1992769744 hasConceptScore W1992769744C169760540 @default.
- W1992769744 hasConceptScore W1992769744C170493617 @default.
- W1992769744 hasConceptScore W1992769744C2775864247 @default.
- W1992769744 hasConceptScore W1992769744C2776134451 @default.
- W1992769744 hasConceptScore W1992769744C2776219046 @default.
- W1992769744 hasConceptScore W1992769744C2777134132 @default.
- W1992769744 hasConceptScore W1992769744C2777828372 @default.
- W1992769744 hasConceptScore W1992769744C2778514916 @default.
- W1992769744 hasConceptScore W1992769744C2779177272 @default.
- W1992769744 hasConceptScore W1992769744C2779343474 @default.
- W1992769744 hasConceptScore W1992769744C2781161787 @default.
- W1992769744 hasConceptScore W1992769744C31487548 @default.
- W1992769744 hasConceptScore W1992769744C513476851 @default.
- W1992769744 hasConceptScore W1992769744C558461103 @default.
- W1992769744 hasConceptScore W1992769744C60644358 @default.
- W1992769744 hasConceptScore W1992769744C71924100 @default.
- W1992769744 hasConceptScore W1992769744C86803240 @default.
- W1992769744 hasIssue "3" @default.
- W1992769744 hasLocation W19927697441 @default.
- W1992769744 hasOpenAccess W1992769744 @default.
- W1992769744 hasPrimaryLocation W19927697441 @default.
- W1992769744 hasRelatedWork W1921712202 @default.
- W1992769744 hasRelatedWork W1971247978 @default.
- W1992769744 hasRelatedWork W2035192770 @default.
- W1992769744 hasRelatedWork W2055855727 @default.
- W1992769744 hasRelatedWork W2071214152 @default.
- W1992769744 hasRelatedWork W2140977657 @default.
- W1992769744 hasRelatedWork W2360832683 @default.
- W1992769744 hasRelatedWork W2371293723 @default.
- W1992769744 hasRelatedWork W2374349362 @default.
- W1992769744 hasRelatedWork W4244053580 @default.
- W1992769744 hasVolume "8" @default.
- W1992769744 isParatext "false" @default.
- W1992769744 isRetracted "false" @default.
- W1992769744 magId "1992769744" @default.
- W1992769744 workType "article" @default.