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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992785510> ?p ?o ?g. }

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• W1992785510 abstract "GAP-43 is one of a small subset of cellular proteins selectively transported by a neuron to its terminals. Its enrichment in growth cones and its increased levels in developing or regenerating neurons suggest that it has an important role in neurite growth. A complementary DNA (cDNA) that encodes rat GAP-43 has been isolated to study its structural characteristics and regulation. The predicted molecular size is 24 kilodaltons, although its migration in SDS-polyacrylamide gels is anomalously retarded. Expression of GAP-43 is limited to the nervous system, where its levels are highest during periods of neurite outgrowth. Nerve growth factor or adenosine 3',5'-monophosphate induction of neurites from PC12 cells is accompanied by increased GAP-43 expression. GAP-43 RNA is easily detectable, although at diminished levels, in the adult rat nervous system. This regulation of GAP-43 is concordant with a role in growth-related processes of the neuron, processes that may continue in the mature animal." @default.
• W1992785510 created "2016-06-24" @default.
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• W1992785510 date "1987-05-01" @default.
• W1992785510 modified "2023-09-27" @default.
• W1992785510 title "Cloning of Complementary DNA for GAP-43, a Neuronal Growth-Related Protein" @default.
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• W1992785510 doi "https://doi.org/10.1126/science.2437653" @default.
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