FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992801219> ?p ?o ?g. }

• W1992801219 endingPage "3014" @default.
• W1992801219 startingPage "3007" @default.
• W1992801219 abstract "Hemin upregulates heme oxygenase-1 (HO-1), a stress-induced enzyme implicated in protection from a variety of injuries while its related isoform HO-2 is constitutively expressed. The role of hemin or HO-1 in the pancreas and their potential modulation of pancreatic injury are unknown. We show that HO-1 is induced in pancreatitis caused by caerulein and more prominently in severe pancreatitis caused by feeding a choline-deficient diet (CDD). Intraperitoneal hemin administration dramatically increases peritoneal and pancreas macrophages that overexpress HO-1 in association with pancreatic induction of the chemoattractants monocyte chemotactic protein-1 and macrophage inflammatory protein-1alpha but not RANTES or macrophage inflammatory protein-2. Hemin administration before CDD feeding protected 8 of 8 mice from lethality while 7 of 16 controls died. Protection is mediated by HO-1-overexpressing macrophages since hemin-primed macrophages home to the pancreas after transfer to naive mice and protect from CDD-induced pancreatitis. Suppression of hemin-primed peritoneal cell HO-1 using HO-1-specific small interfering RNA prior to cell transfer abolishes protection from CDD-induced pancreatitis. Similarly, hemin pretreatment in caerulein-induced pancreatitis reduces serum amylase and lipase, decreases pancreatic trypsin generation, and protects from lung injury. Therefore, hemin-like compounds or hemin-activated macrophages may offer novel therapeutic approaches for preventing acute pancreatitis and its pulmonary complication via upregulation of HO-1." @default.
• W1992801219 created "2016-06-24" @default.
• W1992801219 creator A5007337339 @default.
• W1992801219 creator A5019899805 @default.
• W1992801219 creator A5024267836 @default.
• W1992801219 creator A5035047473 @default.
• W1992801219 creator A5074124766 @default.
• W1992801219 creator A5081671050 @default.
• W1992801219 date "2005-11-01" @default.
• W1992801219 modified "2023-10-17" @default.
• W1992801219 title "Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction" @default.
• W1992801219 cites W1532420525 @default.
• W1992801219 cites W1579488798 @default.
• W1992801219 cites W1600690434 @default.
• W1992801219 cites W1889834301 @default.
• W1992801219 cites W1967207824 @default.
• W1992801219 cites W1973664534 @default.
• W1992801219 cites W1976211445 @default.
• W1992801219 cites W1980653473 @default.
• W1992801219 cites W1988344065 @default.
• W1992801219 cites W1988888487 @default.
• W1992801219 cites W2000755489 @default.
• W1992801219 cites W2003228904 @default.
• W1992801219 cites W2009183800 @default.
• W1992801219 cites W2011313568 @default.
• W1992801219 cites W2014002468 @default.
• W1992801219 cites W2020941408 @default.
• W1992801219 cites W2028778467 @default.
• W1992801219 cites W2031067362 @default.
• W1992801219 cites W2033512036 @default.
• W1992801219 cites W2054496846 @default.
• W1992801219 cites W2064604982 @default.
• W1992801219 cites W2065284764 @default.
• W1992801219 cites W2067714284 @default.
• W1992801219 cites W2070297535 @default.
• W1992801219 cites W2081437288 @default.
• W1992801219 cites W2082942431 @default.
• W1992801219 cites W2086259971 @default.
• W1992801219 cites W2086555099 @default.
• W1992801219 cites W2117419072 @default.
• W1992801219 cites W2120505405 @default.
• W1992801219 cites W2130238034 @default.
• W1992801219 cites W2139648891 @default.
• W1992801219 cites W2162970489 @default.
• W1992801219 cites W2164872793 @default.
• W1992801219 cites W2170662335 @default.
• W1992801219 cites W2318480819 @default.
• W1992801219 cites W82338767 @default.
• W1992801219 cites W2327408917 @default.
• W1992801219 doi "https://doi.org/10.1172/jci24912" @default.
• W1992801219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1257535" @default.
• W1992801219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16239966" @default.
• W1992801219 hasPublicationYear "2005" @default.
• W1992801219 type Work @default.
• W1992801219 sameAs 1992801219 @default.
• W1992801219 citedByCount "117" @default.
• W1992801219 countsByYear W19928012192012 @default.
• W1992801219 countsByYear W19928012192013 @default.
• W1992801219 countsByYear W19928012192014 @default.
• W1992801219 countsByYear W19928012192015 @default.
• W1992801219 countsByYear W19928012192016 @default.
• W1992801219 countsByYear W19928012192017 @default.
• W1992801219 countsByYear W19928012192018 @default.
• W1992801219 countsByYear W19928012192019 @default.
• W1992801219 countsByYear W19928012192020 @default.
• W1992801219 countsByYear W19928012192021 @default.
• W1992801219 countsByYear W19928012192022 @default.
• W1992801219 countsByYear W19928012192023 @default.
• W1992801219 crossrefType "journal-article" @default.
• W1992801219 hasAuthorship W1992801219A5007337339 @default.
• W1992801219 hasAuthorship W1992801219A5019899805 @default.
• W1992801219 hasAuthorship W1992801219A5024267836 @default.
• W1992801219 hasAuthorship W1992801219A5035047473 @default.
• W1992801219 hasAuthorship W1992801219A5074124766 @default.
• W1992801219 hasAuthorship W1992801219A5081671050 @default.
• W1992801219 hasBestOaLocation W19928012191 @default.
• W1992801219 hasConcept C126322002 @default.
• W1992801219 hasConcept C134018914 @default.
• W1992801219 hasConcept C181199279 @default.
• W1992801219 hasConcept C185592680 @default.
• W1992801219 hasConcept C2775967933 @default.
• W1992801219 hasConcept C2776217839 @default.
• W1992801219 hasConcept C2776670229 @default.
• W1992801219 hasConcept C2777723881 @default.
• W1992801219 hasConcept C2778764654 @default.
• W1992801219 hasConcept C2779219270 @default.
• W1992801219 hasConcept C55493867 @default.
• W1992801219 hasConcept C71924100 @default.
• W1992801219 hasConceptScore W1992801219C126322002 @default.
• W1992801219 hasConceptScore W1992801219C134018914 @default.
• W1992801219 hasConceptScore W1992801219C181199279 @default.
• W1992801219 hasConceptScore W1992801219C185592680 @default.
• W1992801219 hasConceptScore W1992801219C2775967933 @default.
• W1992801219 hasConceptScore W1992801219C2776217839 @default.
• W1992801219 hasConceptScore W1992801219C2776670229 @default.
• W1992801219 hasConceptScore W1992801219C2777723881 @default.
• W1992801219 hasConceptScore W1992801219C2778764654 @default.
• W1992801219 hasConceptScore W1992801219C2779219270 @default.

• next