Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992802352> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1992802352 endingPage "17" @default.
- W1992802352 startingPage "17" @default.
- W1992802352 abstract "Back to table of contents Previous article Next article Clinical & Research NewsFull AccessDo Oxytocin Gene Variants Protect Against Mental Illness?Joan Arehart-TreichelJoan Arehart-TreichelSearch for more papers by this authorPublished Online:4 Feb 2011https://doi.org/10.1176/pn.46.3.psychnews_46_3_025AbstractWhy are certain people more upbeat—that is, less susceptible to depression and anxiety—than others are? It has been suggested that the long (L) variant of the serotonin transporter gene—the 5-HTTLPR gene—might be one reason. For example, the L variant had been linked with less depression in the presence of stressful events.But now it looks as if a particular variant of the oxytocin receptor gene—the T variant—might be another reason, German researchers reported online December 24, 2010, in Biological Psychiatry. The lead investigator was Christian Montag, Ph.D., of the University of Bonn.The study sample consisted of 750 students at two German universities—the University of Bonn and the University of Heidelberg. Subjects were evaluated to see whether they possessed an SS variant of the serotonin transporter gene, an SL variant of the gene, or an LL variant of the gene.They were also evaluated to see whether they possessed a CC variant of the oxytocin receptor gene, a CT variant of the gene, or a TT variant of the gene.In addition, researchers used the Affective Neuroscience Personality Scale to assess subjects' personality dimensions of sadness and fear.Since the T variant of the oxytocin receptor gene had been linked by the researchers in an unpublished study with greater trust, and since an inverse relationship between trust and anxiety had been found in another study, Montag and his team hypothesized that subjects having the LL variant of the serotonin transporter gene plus the TT variant of the oxytocin receptor gene would have the lowest sadness and fear scores.Their results confirmed their hypothesis. The lowest sadness and fear scores were found in subjects having two L copies of the serotonin transporter gene plus two T copies of the oxytocin receptor gene. Those having other variant combinations scored higher on sadness and fear.Previous studies of oxytocin have found that it has some antianxiety properties as well as some pro-social ones such as enhancement of social interactions, formation of human attachments, and increased trust (Psychiatric News, November 21, 2008), but not antidepressive properties.The researchers anticipate that at some future point, not only the SSRI antidepressants, but oxytocin might be used to treat a wide array of psychiatric disorders depending on people's particular genetic constellations for serotonin and oxytocin in the brain.Indeed, oxytocin or its analogs thereof, are already being tested to see whether they might have value as antianxiety or social-promoting medications—for instance, whether they might be able to attenuate fear in people with social anxiety disorder or generalized anxiety disorder, or whether they might be able to correct the social deficits experienced by people with autism spectrum disorders or schizophrenia (Psychiatric News, November 21, 2008).The study was funded by the German Research Association.An abstract of “Interaction of 5-HTTLPR and a Variation on the Oxytocin Receptor Gene Influences Negative Emotionality” is posted at <www.biologicalpsychiatryjournal.com/article/S0006-3223(10)01158-3/abstract>. ISSUES NewArchived" @default.
- W1992802352 created "2016-06-24" @default.
- W1992802352 creator A5060676321 @default.
- W1992802352 date "2011-02-04" @default.
- W1992802352 modified "2023-09-26" @default.
- W1992802352 title "Do Oxytocin Gene Variants Protect Against Mental Illness?" @default.
- W1992802352 doi "https://doi.org/10.1176/pn.46.3.psychnews_46_3_025" @default.
- W1992802352 hasPublicationYear "2011" @default.
- W1992802352 type Work @default.
- W1992802352 sameAs 1992802352 @default.
- W1992802352 citedByCount "0" @default.
- W1992802352 crossrefType "journal-article" @default.
- W1992802352 hasAuthorship W1992802352A5060676321 @default.
- W1992802352 hasConcept C104317684 @default.
- W1992802352 hasConcept C11171543 @default.
- W1992802352 hasConcept C118552586 @default.
- W1992802352 hasConcept C135763542 @default.
- W1992802352 hasConcept C139719470 @default.
- W1992802352 hasConcept C154775046 @default.
- W1992802352 hasConcept C15744967 @default.
- W1992802352 hasConcept C162324750 @default.
- W1992802352 hasConcept C166957645 @default.
- W1992802352 hasConcept C169760540 @default.
- W1992802352 hasConcept C181612422 @default.
- W1992802352 hasConcept C187288502 @default.
- W1992802352 hasConcept C2776176026 @default.
- W1992802352 hasConcept C2776867660 @default.
- W1992802352 hasConcept C2778897192 @default.
- W1992802352 hasConcept C2779302386 @default.
- W1992802352 hasConcept C2779812673 @default.
- W1992802352 hasConcept C54355233 @default.
- W1992802352 hasConcept C558461103 @default.
- W1992802352 hasConcept C86803240 @default.
- W1992802352 hasConcept C95457728 @default.
- W1992802352 hasConceptScore W1992802352C104317684 @default.
- W1992802352 hasConceptScore W1992802352C11171543 @default.
- W1992802352 hasConceptScore W1992802352C118552586 @default.
- W1992802352 hasConceptScore W1992802352C135763542 @default.
- W1992802352 hasConceptScore W1992802352C139719470 @default.
- W1992802352 hasConceptScore W1992802352C154775046 @default.
- W1992802352 hasConceptScore W1992802352C15744967 @default.
- W1992802352 hasConceptScore W1992802352C162324750 @default.
- W1992802352 hasConceptScore W1992802352C166957645 @default.
- W1992802352 hasConceptScore W1992802352C169760540 @default.
- W1992802352 hasConceptScore W1992802352C181612422 @default.
- W1992802352 hasConceptScore W1992802352C187288502 @default.
- W1992802352 hasConceptScore W1992802352C2776176026 @default.
- W1992802352 hasConceptScore W1992802352C2776867660 @default.
- W1992802352 hasConceptScore W1992802352C2778897192 @default.
- W1992802352 hasConceptScore W1992802352C2779302386 @default.
- W1992802352 hasConceptScore W1992802352C2779812673 @default.
- W1992802352 hasConceptScore W1992802352C54355233 @default.
- W1992802352 hasConceptScore W1992802352C558461103 @default.
- W1992802352 hasConceptScore W1992802352C86803240 @default.
- W1992802352 hasConceptScore W1992802352C95457728 @default.
- W1992802352 hasIssue "3" @default.
- W1992802352 hasLocation W19928023521 @default.
- W1992802352 hasOpenAccess W1992802352 @default.
- W1992802352 hasPrimaryLocation W19928023521 @default.
- W1992802352 hasRelatedWork W1981279109 @default.
- W1992802352 hasRelatedWork W2055669556 @default.
- W1992802352 hasRelatedWork W2056619366 @default.
- W1992802352 hasRelatedWork W2071091563 @default.
- W1992802352 hasRelatedWork W2072921494 @default.
- W1992802352 hasRelatedWork W2113140454 @default.
- W1992802352 hasRelatedWork W2230907131 @default.
- W1992802352 hasRelatedWork W4223638967 @default.
- W1992802352 hasRelatedWork W4294200416 @default.
- W1992802352 hasRelatedWork W4297984567 @default.
- W1992802352 hasVolume "46" @default.
- W1992802352 isParatext "false" @default.
- W1992802352 isRetracted "false" @default.
- W1992802352 magId "1992802352" @default.
- W1992802352 workType "article" @default.