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• W1992804898 endingPage "1438" @default.
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• W1992804898 abstract "ABSTRACT One important function of the human adenovirus E1B 55-kDa protein is induction of selective nuclear export of viral late mRNAs. This protein interacts with the viral E4 Orf6 and four cellular proteins to form an infected-cell-specific E3 ubiquitin ligase. The assembly of this enzyme is required for efficient viral late mRNA export, but neither the relevant substrates nor the cellular pathway that exports viral late mRNAs has been identified. We therefore examined the effects on viral late gene expression of inhibition of the synthesis or activity of the mRNA export receptor Nxf1, which was observed to colocalize with the E1B 55-kDa protein in infected cells. When production of Nxf1 was impaired by using RNA interference, the efficiency of viral late mRNA export was reduced to a corresponding degree. Furthermore, synthesis of a dominant-negative derivative of Nxf1 during the late phase of infection interfered with production of a late structural protein. These observations indicate that the Nxf1 pathway is responsible for export of viral late mRNAs. As the infected-cell-specific E3 ubiquitin ligase targets its known substrates for proteasomal degradation, we compared the concentrations of several components of this pathway (Nxf1, Thox1, and Thoc4) in infected cells that did or did not contain this enzyme. Although the concentration of a well-established substrate, Mre11, decreased significantly in cells infected by adenovirus type 5 (Ad5), but not in those infected by the E1B 55-kDa protein-null mutant Hr6, no E1B 55-kDa protein-dependent degradation of the Nxf1 pathway proteins was observed." @default.
• W1992804898 created "2016-06-24" @default.
• W1992804898 creator A5035988196 @default.
• W1992804898 creator A5039212782 @default.
• W1992804898 creator A5044542409 @default.
• W1992804898 date "2011-02-15" @default.
• W1992804898 modified "2023-10-11" @default.
• W1992804898 title "Export of Adenoviral Late mRNA from the Nucleus Requires the Nxf1/Tap Export Receptor" @default.
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• W1992804898 doi "https://doi.org/10.1128/jvi.02108-10" @default.
• W1992804898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3028892" @default.
• W1992804898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21123381" @default.
• W1992804898 hasPublicationYear "2011" @default.
• W1992804898 type Work @default.
• W1992804898 sameAs 1992804898 @default.

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