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- W1992808267 abstract "Two novel compounds, kodaistatin A, C35H34O11, molecular weight 630, and kodaistatin C, C35H34O12, molecular weight 646, have been isolated from cultures of Aspergillus terreus Thom DSM 11247 by solid-phase extraction, size-exclusion chromatography, and various preparative HPLC steps. The use of a range of 2D NMR measurements, in particular 13C-13C correlation measurements, has led to the clarification of the structure of kodaistatin A. Kodaistatin C is a hydroxylated derivative of kodaistatin A. Both natural products contain hydroxylated aspulvinones and identical highly substituted polyketide units. An X-ray single crystal structure analysis of aspulvinon E demonstrated the z-configuration at the central double bond. The kodaistatins are effective inhibitors of the glucose-6-phosphate translocase component of the glucose-6-phosphatase system (EC 3.1.3.9), an enzyme system which is important for the control of blood glucose levels. The IC50 is 80 nM for kodaistatin A and 130nM for kodaistatin C." @default.
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- W1992808267 date "2000-01-01" @default.
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- W1992808267 title "Kodaistatins, Novel Inhibitors of Glucose-6-phosphate Translocase T1 from Aspergillus terreus Thom DSM 11247. Isolation and Structural Elucidation." @default.
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- W1992808267 doi "https://doi.org/10.7164/antibiotics.53.677" @default.
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