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- W1992819691 abstract "Intraperitoneal administration of R(-)- and S(+)-flurbiprofen resulted in dose dependent antinociceptive behavior in the rat paw formalin test. S(+)-flurbiprofen was significantly more potent than the non-cyclooxygenase inhibiting R(-)-enantiomer with a potency ratio of about 3 to 1. Chiral inversion was very low and does not seem to account for the action of R(-)-flurbiprofen. In a modified Randall Selitto assay also both enantiomers were active in a dose dependent manner following systemic administration. Following local administration into the inflamed paw only S(+)-flurbiprofen showed significant dose related antinociceptive effects. R(-)-flurbiprofen was unable to block prostaglandin E2 induced hyperalgesia following local administration. Consequently, a central site of action independent of prostaglandin synthesis inhibition has to be discussed with respect to antinociceptive activity following systemic administration." @default.
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- W1992819691 date "1994-01-01" @default.
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- W1992819691 title "Antinociceptive actions of R(−)-flurbiprofen - a non-cyclooxygenase inhibiting 2-arylpropionic acid - in rats" @default.
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- W1992819691 doi "https://doi.org/10.1016/0024-3205(94)00555-9" @default.
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