FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992820921> ?p ?o ?g. }

• W1992820921 endingPage "67" @default.
• W1992820921 startingPage "59" @default.
• W1992820921 abstract "Metabolic activation of drugs frequently generates electrophilic products that may undergo covalent binding to biological macromolecules, such as proteins and DNA. The resulting covalent adducts are of considerable concern in drug discovery and development. Several strategies for assessing the potential risks of candidate drugs have been reported. Of these, glutathione trapping is the most commonly used method together with mass spectrometry. Furthermore, drug-mediated protein modifications have been studied using serum albumin and CYP enzymes to clarify target amino acids and mechanism-based inhibition, respectively. In this article, we introduce a practical way to screen drug-mediated protein modifications. The method, referred to as “predicted multiple selected reaction monitoring,” is based on the selected reaction monitoring (SRM) strategy, but targets all possible chemically modified tryptic peptides. The creation of SRM lists may require patience; however, this strategy could facilitate more sensitive screening compared with the common strategy of data-dependent product ion scanning. Ketoprofen-N-hydroxysuccinimidyl ester (equivalent to glucuronide) and N-acetyl-p-benzoquinone imine (NAPQI) were allowed to react with human serum albumin as a model experiment. Using this strategy, 11 ketoprofen-adduction sites (at Lys137, 195, 199, 212, 351, 402, 432, 436, 525, 536, and 541) and 1 NAPQI-adduction site (at Cys34) were easily identified." @default.
• W1992820921 created "2016-06-24" @default.
• W1992820921 creator A5003571844 @default.
• W1992820921 creator A5005526311 @default.
• W1992820921 creator A5007519814 @default.
• W1992820921 creator A5084140379 @default.
• W1992820921 date "2014-03-01" @default.
• W1992820921 modified "2023-09-30" @default.
• W1992820921 title "Predicted multiple selected reaction monitoring to screen activated drug-mediated modifications on human serum albumin" @default.
• W1992820921 cites W1966746955 @default.
• W1992820921 cites W1968687693 @default.
• W1992820921 cites W1989536406 @default.
• W1992820921 cites W1991669717 @default.
• W1992820921 cites W1993652628 @default.
• W1992820921 cites W1996935441 @default.
• W1992820921 cites W1997486990 @default.
• W1992820921 cites W2007092154 @default.
• W1992820921 cites W2009480985 @default.
• W1992820921 cites W2014239314 @default.
• W1992820921 cites W2022560747 @default.
• W1992820921 cites W2025422229 @default.
• W1992820921 cites W2028908020 @default.
• W1992820921 cites W2033935070 @default.
• W1992820921 cites W2035974929 @default.
• W1992820921 cites W2051773486 @default.
• W1992820921 cites W2063093761 @default.
• W1992820921 cites W2063855838 @default.
• W1992820921 cites W2070376255 @default.
• W1992820921 cites W2079843936 @default.
• W1992820921 cites W2083266527 @default.
• W1992820921 cites W2084732255 @default.
• W1992820921 cites W2093411723 @default.
• W1992820921 cites W2096084510 @default.
• W1992820921 cites W2101553565 @default.
• W1992820921 cites W2110015208 @default.
• W1992820921 cites W2120016245 @default.
• W1992820921 cites W2126945573 @default.
• W1992820921 cites W2127402560 @default.
• W1992820921 cites W2134628252 @default.
• W1992820921 cites W2139683082 @default.
• W1992820921 cites W2140640244 @default.
• W1992820921 cites W2141567033 @default.
• W1992820921 cites W2153936380 @default.
• W1992820921 cites W2166537701 @default.
• W1992820921 cites W2170550655 @default.
• W1992820921 doi "https://doi.org/10.1016/j.ab.2013.12.016" @default.
• W1992820921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24361714" @default.
• W1992820921 hasPublicationYear "2014" @default.
• W1992820921 type Work @default.
• W1992820921 sameAs 1992820921 @default.
• W1992820921 citedByCount "14" @default.
• W1992820921 countsByYear W19928209212014 @default.
• W1992820921 countsByYear W19928209212015 @default.
• W1992820921 countsByYear W19928209212016 @default.
• W1992820921 countsByYear W19928209212017 @default.
• W1992820921 countsByYear W19928209212018 @default.
• W1992820921 countsByYear W19928209212019 @default.
• W1992820921 countsByYear W19928209212020 @default.
• W1992820921 countsByYear W19928209212023 @default.
• W1992820921 crossrefType "journal-article" @default.
• W1992820921 hasAuthorship W1992820921A5003571844 @default.
• W1992820921 hasAuthorship W1992820921A5005526311 @default.
• W1992820921 hasAuthorship W1992820921A5007519814 @default.
• W1992820921 hasAuthorship W1992820921A5084140379 @default.
• W1992820921 hasConcept C108204754 @default.
• W1992820921 hasConcept C161790260 @default.
• W1992820921 hasConcept C162356407 @default.
• W1992820921 hasConcept C165616093 @default.
• W1992820921 hasConcept C178790620 @default.
• W1992820921 hasConcept C180577832 @default.
• W1992820921 hasConcept C185592680 @default.
• W1992820921 hasConcept C21951064 @default.
• W1992820921 hasConcept C2780035454 @default.
• W1992820921 hasConcept C31827203 @default.
• W1992820921 hasConcept C43617362 @default.
• W1992820921 hasConcept C50027330 @default.
• W1992820921 hasConcept C55493867 @default.
• W1992820921 hasConcept C86803240 @default.
• W1992820921 hasConcept C98274493 @default.
• W1992820921 hasConceptScore W1992820921C108204754 @default.
• W1992820921 hasConceptScore W1992820921C161790260 @default.
• W1992820921 hasConceptScore W1992820921C162356407 @default.
• W1992820921 hasConceptScore W1992820921C165616093 @default.
• W1992820921 hasConceptScore W1992820921C178790620 @default.
• W1992820921 hasConceptScore W1992820921C180577832 @default.
• W1992820921 hasConceptScore W1992820921C185592680 @default.
• W1992820921 hasConceptScore W1992820921C21951064 @default.
• W1992820921 hasConceptScore W1992820921C2780035454 @default.
• W1992820921 hasConceptScore W1992820921C31827203 @default.
• W1992820921 hasConceptScore W1992820921C43617362 @default.
• W1992820921 hasConceptScore W1992820921C50027330 @default.
• W1992820921 hasConceptScore W1992820921C55493867 @default.
• W1992820921 hasConceptScore W1992820921C86803240 @default.
• W1992820921 hasConceptScore W1992820921C98274493 @default.
• W1992820921 hasLocation W19928209211 @default.
• W1992820921 hasLocation W19928209212 @default.
• W1992820921 hasOpenAccess W1992820921 @default.
• W1992820921 hasPrimaryLocation W19928209211 @default.

• next